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Sökning: onr:"swepub:oai:lup.lub.lu.se:1316a7e3-b433-4920-8212-6a4d10135e76" > First infant formul...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004805naa a2200541 4500
001oai:lup.lub.lu.se:1316a7e3-b433-4920-8212-6a4d10135e76
003SwePub
008170616s2017 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/1316a7e3-b433-4920-8212-6a4d10135e762 URI
0247 a https://doi.org/10.2337/dc16-16242 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Hummel, Sandrau Technical University of Munich4 aut
2451 0a First infant formula type and risk of islet autoimmunity in the environmental determinants of diabetes in the young (TEDDY) study
264 c 2017-01-17
264 1b American Diabetes Association,c 2017
300 a 7 s.
520 a OBJECTIVE Studies on the introduction of infant formulas and its effect on the risk of islet autoimmunity and type 1 diabetes (T1D) have yielded inconsistent results. We investigated whether the introduction of formula based on hydrolyzed cow'smilk as the first formula is associated with reduced islet autoimmunity risk in a large prospective cohort. RESEARCH DESIGN AND METHODS The Environmental Determinants of Diabetes in the Young (TEDDY) study prospectively monitors 8,676 children at increased genetic risk for T1D. Autoantibodies to insulin, GAD65, and IA2 were measured regularly to define islet autoimmunity. Information on formula feeding was collected by questionnaires at 3 months of age. RESULTS In survival analyses, after adjustment for family history with T1D, HLA genotype, sex, country, delivery mode, breast-feeding 3 months, and seasonality of birth, we observed no significant association with islet autoimmunity in infants who received extensively hydrolyzed compared with nonhydrolyzed cow'smilk-based formula as the first formula during the first 3 months (adjusted hazard ratio 1.38 [95% CI 0.95; 2.01]), and a significantly increased risk for extensively hydrolyzed formula introduced during the first 7 days (adjusted hazard ratio 1.57 [1.04; 2.38]). Using a partially hydrolyzed or other formula as the first formula, or no formula, was not associated with islet autoimmunity risk. CONCLUSIONS These results add to the existing evidence that islet autoimmunity risk is not reduced, and may be increased, by using hydrolyzed compared with nonhydrolyzed cow's milk-based infant formula as the first formula in infants at increased genetic risk for T1D .
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Beyerlein, Andreasu Technical University of Munich4 aut
7001 a Tamura, Roy N.u University of South Florida4 aut
7001 a Uusitalo, Ullau University of South Florida4 aut
7001 a Andŕen Aronsson, Carinu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)smi-can
7001 a Yang, Jiminu University of South Florida4 aut
7001 a Riikonen, Anneu University of Tampere4 aut
7001 a Lernmark, Akeu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)endo-ale
7001 a Rewers, Marian J.u University of Colorado4 aut
7001 a Hagopian, William A.u Pacific Northwest Research Institute4 aut
7001 a She, Jin-Xiongu Medical College of Georgia4 aut
7001 a Simell, Olli G.u Turku University Hospital4 aut
7001 a Toppari, Jormau Turku University Hospital4 aut
7001 a Ziegler, Anette-Gu Technical University of Munich4 aut
7001 a Akolkar, Beena4 aut
7001 a Krischer, Jeffrey P.u University of South Florida4 aut
7001 a Virtanen, Suvi Mu University of Tampere4 aut
7001 a Norris, Jill M4 aut
7102 a Technical University of Munichb University of South Florida4 org
7730 t Diabetes Cared : American Diabetes Associationg 40:3, s. 398-404q 40:3<398-404x 0149-5992x 1935-5548
8564 u http://dx.doi.org/10.2337/dc16-1624y FULLTEXT
8564 u https://care.diabetesjournals.org/content/diacare/40/3/398.full.pdf
8564 8u https://lup.lub.lu.se/record/1316a7e3-b433-4920-8212-6a4d10135e76
8564 8u https://doi.org/10.2337/dc16-1624

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