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Magnetic Resonance ...
Magnetic Resonance Spectroscopy in Schizophrenia : Evidence for Glutamatergic Dysfunction and Impaired Energy Metabolism
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- Duarte, João M.N. (författare)
- Lund University,Lunds universitet,Diabetes och hjärnans funktion,Forskargrupper vid Lunds universitet,Diabetes and Brain Function,Lund University Research Groups
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- Xin, Lijing (författare)
- Swiss Federal Institute of Technology
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(creator_code:org_t)
- 2018-04-03
- 2019
- Engelska 15 s.
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Ingår i: Neurochemical Research. - : Springer Science and Business Media LLC. - 0364-3190 .- 1573-6903. ; 44:1, s. 102-116
- Relaterad länk:
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Abstract
Ämnesord
Stäng
- In the past couple of decades, major efforts were made to increase reliability of metabolic assessments by magnetic resonance methods. Magnetic resonance spectroscopy (MRS) has been valuable for providing in vivo evidence and investigating biomarkers in neuropsychiatric disorders, namely schizophrenia. Alterations of glutamate and glutamine levels in brains of schizophrenia patients relative to healthy subjects are generally interpreted as markers of glutamatergic dysfunction. However, only a small fraction of MRS-detectable glutamate is involved in neurotransmission. Here we review and discuss brain metabolic processes that involve glutamate and that are likely to be implicated in neuropsychiatric disorders.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Glutamate
- Glutamine
- Magnetic resonance
- Metabolism
- Schizophrenia
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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