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Regional expression...
Regional expression of the MAPT gene is associated with loss of hubs in brain networks and cognitive impairment in Parkinson disease and progressive supranuclear palsy
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- Rittman, Timothy (författare)
- University of Cambridge
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- Rubinov, Mikail (författare)
- University of Cambridge
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- Vértes, Petra E (författare)
- University of Cambridge
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- Patel, Ameera X (författare)
- University of Cambridge
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- Ginestet, Cedric E (författare)
- King's College London
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- Ghosh, Boyd C P (författare)
- University Hospital Southampton
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- Barker, Roger A (författare)
- Lund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Developmental and Regenerative Neurobiology,Lund University Research Groups
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- Spillantini, Maria Grazia (författare)
- University of Cambridge
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- Bullmore, Edward T (författare)
- University of Cambridge
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- Rowe, James B (författare)
- University of Cambridge
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska 8 s.
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Ingår i: Neurobiology of Aging. - : Elsevier BV. - 0197-4580. ; 48, s. 153-160
- Relaterad länk:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Abnormalities of tau protein are central to the pathogenesis of progressive supranuclear palsy, whereas haplotype variation of the tau gene MAPT influences the risk of Parkinson disease and Parkinson's disease dementia. We assessed whether regional MAPT expression might be associated with selective vulnerability of global brain networks to neurodegenerative pathology. Using task-free functional magnetic resonance imaging in progressive supranuclear palsy, Parkinson disease, and healthy subjects (n = 128), we examined functional brain networks and measured the connection strength between 471 gray matter regions. We obtained MAPT and SNCA microarray expression data in healthy subjects from the Allen brain atlas. Regional connectivity varied according to the normal expression of MAPT. The regional expression of MAPT correlated with the proportionate loss of regional connectivity in Parkinson's disease. Executive cognition was impaired in proportion to the loss of hub connectivity. These effects were not seen with SNCA, suggesting that alpha-synuclein pathology is not mediated through global network properties. The results establish a link between regional MAPT expression and selective vulnerability of functional brain networks to neurodegeneration.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Parkinson disease
- supranuclear palsy
- MAPT gene
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Rittman, Timothy
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Rubinov, Mikail
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Vértes, Petra E
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Patel, Ameera X
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Ginestet, Cedric ...
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Ghosh, Boyd C P
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visa fler...
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Barker, Roger A
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Spillantini, Mar ...
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Bullmore, Edward ...
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Rowe, James B
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Neurobiology of ...
- Av lärosätet
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Lunds universitet