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A large cohort stud...
A large cohort study of the effects of Lewis, ABO, 13 other blood groups, and secretor status on COVID-19 susceptibility, severity, and long COVID-19
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- Moslemi, Camous (författare)
- Zealand University Hospital
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- Sækmose, Susanne (författare)
- Zealand University Hospital
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- Larsen, Rune (författare)
- Zealand University Hospital
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- Brodersen, Thorsten (författare)
- Zealand University Hospital
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- Didriksen, Maria (författare)
- Copenhagen University Hospital
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- Hjalgrim, Henrik (författare)
- Aarhus University Hospital
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- Banasik, Karina (författare)
- University of Copenhagen
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- Nielsen, Kaspar R. (författare)
- Aalborg University Hospital
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- Bruun, Mie T. (författare)
- Odense University Hospital
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- Dowsett, Joseph (författare)
- Copenhagen University Hospital
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- Kasperen, Kathrine A. (författare)
- Danish Cancer Society,Aarhus University
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- Mikkelsen, Susan (författare)
- Danish Cancer Society
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- Hansen, Thomas F. (författare)
- Copenhagen University Hospital,University of Copenhagen
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- Ullum, Henrik (författare)
- Danish Serum Institute, Copenhagen
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- Erikstrup, Christian (författare)
- Danish Cancer Society
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- Olsson, Martin L. (författare)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Transfusionsmedicin,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Transfusion Medicine,Lund University Research Groups
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- Ostrowski, Sisse R. (författare)
- University of Copenhagen,Copenhagen University Hospital
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- Pedersen, Ole B. (författare)
- Zealand University Hospital,University of Copenhagen
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(creator_code:org_t)
- 2022-11-03
- 2023
- Engelska.
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Ingår i: Transfusion. - : Wiley. - 0041-1132 .- 1537-2995. ; 63:1, s. 47-58
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Previous studies have reported Blood type O to confer a lower risk of SARS-CoV-2 infection, while secretor status and other blood groups have been suspected to have a similar effect as well. Study design and methods: To determine whether any other blood groups influence testing positive for SARS-CoV-2, COVID-19 severity, or prolonged COVID-19, we used a large cohort of 650,156 Danish blood donors with varying available data for secretor status and blood groups ABO, Rh, Colton, Duffy, Diego, Dombrock, Kell, Kidd, Knops, Lewis, Lutheran, MNS, P1PK, Vel, and Yt. Of these, 36,068 tested positive for SARS-CoV-2 whereas 614,088 tested negative between 2020-02-17 and 2021-08-04. Associations between infection and blood groups were assessed using logistic regression models with sex and age as covariates. Results: The Lewis blood group antigen Lea displayed strongly reduced SARS-CoV-2 susceptibility OR 0.85 CI[0.79–0.93] p <.001. Compared to blood type O, the blood types B, A, and AB were found more susceptible toward infection with ORs 1.1 CI[1.06–1.14] p <.001, 1.17 CI[1.14–1.2] p <.001, and 1.2 CI[1.14–1.26] p <.001, respectively. No susceptibility associations were found for the other 13 blood groups investigated. There was no association between any blood groups and COVID-19 hospitalization or long COVID-19. No secretor status associations were found. Discussion: This study uncovers a new association to reduced SARS-CoV-2 susceptibility for Lewis type Lea and confirms the previous link to blood group O. The new association to Lea could be explained by a link between mucosal microbiome and SARS-CoV-2.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- ABO
- blood antigen
- blood groups
- blood systems
- COVID hospitalization
- COVID severity
- COVID susceptibility
- COVID-19
- Diego
- Dombrock
- Duffy
- FUT2
- FUT3
- Kell
- Kidd
- Knops
- Lewis
- long COVID symptoms
- long COVID-19
- Lutheran
- MNS
- P1PK
- Rh
- SARS-CoV-2
- secretor
- Vel
- Yt
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Moslemi, Camous
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Sækmose, Susanne
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Larsen, Rune
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Brodersen, Thors ...
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Didriksen, Maria
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Hjalgrim, Henrik
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Banasik, Karina
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Nielsen, Kaspar ...
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Bruun, Mie T.
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Dowsett, Joseph
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Kasperen, Kathri ...
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Mikkelsen, Susan
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Hansen, Thomas F ...
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Ullum, Henrik
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Erikstrup, Chris ...
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Olsson, Martin L ...
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Ostrowski, Sisse ...
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Pedersen, Ole B.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
- Artiklar i publikationen
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Transfusion
- Av lärosätet
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Lunds universitet