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Plasma IAPP-Autoant...
Plasma IAPP-Autoantibody Levels in Alzheimer’s Disease Patients Are Affected by APOE4 Status
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- Pocevičiūtė, Dovilė (författare)
- Lund University,Lunds universitet,Kognitiv sjukdomsforskning,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Cognitive disorders,Department of Clinical Sciences, Malmö,Faculty of Medicine,Cognitive Disorder Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
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- Roth, Bodil (författare)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Department of Internal Medicine, Lund University, Skåne University Hospital, Malmö, Sweden
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- Schultz, Nina (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden
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- Nuñez-Diaz, Cristina (författare)
- Lund University,Lunds universitet,Kognitiv sjukdomsforskning,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Cognitive disorders,Department of Clinical Sciences, Malmö,Faculty of Medicine,Skåne University Hospital,Cognitive Disorder Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
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- Janelidze, Shorena (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden
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- Olofsson, Anders, 1970- (författare)
- Umeå universitet,Umeå University,Institutionen för medicinsk kemi och biofysik
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- Hansson, Oskar (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden; Memory Clinic, Skåne University Hospital, Malmö, Sweden
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- Wennström, Malin (författare)
- Lund University,Lunds universitet,Kognitiv sjukdomsforskning,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Cognitive disorders,Department of Clinical Sciences, Malmö,Faculty of Medicine,Cognitive Disorder Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
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(creator_code:org_t)
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- 2023-02-14
- 2023
- Engelska.
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Ingår i: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 24:4
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Pancreas-derived islet amyloid polypeptide (IAPP) crosses the blood–brain barrier and co-deposits with amyloid beta (Aβ) in brains of type 2 diabetes (T2D) and Alzheimer’s disease (AD) patients. Depositions might be related to the circulating IAPP levels, but it warrants further investigation. Autoantibodies recognizing toxic IAPP oligomers (IAPPO) but not monomers (IAPPM) or fibrils have been found in T2D, but studies on AD are lacking. In this study, we have analyzed plasma from two cohorts and found that levels of neither immunoglobulin (Ig) M, nor IgG or IgA against IAPPM or IAPPO were altered in AD patients compared with controls. However, our results show significantly lower IAPPO-IgA levels in apolipoprotein E (APOE) 4 carriers compared with non-carriers in an allele dose-dependent manner, and the decrease is linked to the AD pathology. Furthermore, plasma IAPP-Ig levels, especially IAPP-IgA, correlated with cognitive decline, C-reactive protein, cerebrospinal fluid Aβ and tau, neurofibrillary tangles, and brain IAPP exclusively in APOE4 non-carriers. We speculate that the reduction in IAPPO-IgA levels may be caused by increased plasma IAPPO levels or masked epitopes in APOE4 carriers and propose that IgA and APOE4 status play a specific role in clearance of circulatory IAPPO, which may influence the amount of IAPP deposition in the AD brain.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- AD
- amylin
- amyloid beta
- APOE4
- autoantibodies
- cognition
- IgA
- IgG
- IgM
- T2D
- AD
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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