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Combining plasma Aβ...
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Niimi, YoshikiUniversity of Tokyo Hospital
(författare)
Combining plasma Aβ and p-tau217 improves detection of brain amyloid in non-demented elderly
- Artikel/kapitelEngelska2024
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:1a5bad38-6c34-4c00-934a-41043a446d39
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https://lup.lub.lu.se/record/1a5bad38-6c34-4c00-934a-41043a446d39URI
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https://doi.org/10.1186/s13195-024-01469-wDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Background: Maximizing the efficiency to screen amyloid-positive individuals in asymptomatic and non-demented aged population using blood-based biomarkers is essential for future success of clinical trials in the early stage of Alzheimer’s disease (AD). In this study, we elucidate the utility of combination of plasma amyloid-β (Aβ)-related biomarkers and tau phosphorylated at threonine 217 (p-tau217) to predict abnormal Aβ-positron emission tomography (PET) in the preclinical and prodromal AD. Methods: We designed the cross-sectional study including two ethnically distinct cohorts, the Japanese trial-ready cohort for preclinica and prodromal AD (J-TRC) and the Swedish BioFINDER study. J-TRC included 474 non-demented individuals (CDR 0: 331, CDR 0.5: 143). Participants underwent plasma Aβ and p-tau217 assessments, and Aβ-PET imaging. Findings in J-TRC were replicated in the BioFINDER cohort including 177 participants (cognitively unimpaired: 114, mild cognitive impairment: 63). In both cohorts, plasma Aβ(1-42) (Aβ42) and Aβ(1-40) (Aβ40) were measured using immunoprecipitation-MALDI TOF mass spectrometry (Shimadzu), and p-tau217 was measured with an immunoassay on the Meso Scale Discovery platform (Eli Lilly). Results: Aβ-PET was abnormal in 81 participants from J-TRC and 71 participants from BioFINDER. Plasma Aβ42/Aβ40 ratio and p-tau217 individually showed moderate to high accuracies when detecting abnormal Aβ-PET scans, which were improved by combining plasma biomarkers and by including age, sex and APOE genotype in the models. In J-TRC, the highest AUCs were observed for the models combining p-tau217/Aβ42 ratio, APOE, age, sex in the whole cohort (AUC = 0.936), combining p-tau217, Aβ42/Aβ40 ratio, APOE, age, sex in the CDR 0 group (AUC = 0.948), and combining p-tau217/Aβ42 ratio, APOE, age, sex in the CDR 0.5 group (AUC = 0.955), respectively. Each subgroup results were replicated in BioFINDER, where the highest AUCs were seen for models combining p-tau217, Aβ42/40 ratio, APOE, age, sex in cognitively unimpaired (AUC = 0.938), and p-tau217/Aβ42 ratio, APOE, age, sex in mild cognitive impairment (AUC = 0.914). Conclusions: Combination of plasma Aβ-related biomarkers and p-tau217 exhibits high performance when predicting Aβ-PET positivity. Adding basic clinical information (i.e., age, sex, APOE ε genotype) improved the prediction in preclinical AD, but not in prodromal AD. Combination of Aβ-related biomarkers and p-tau217 could be highly useful for pre-screening of participants in clinical trials of preclinical and prodromal AD.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Janelidze, ShorenaLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas(Swepub:lu)nkir-sje
(författare)
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Sato, KenichiroGraduate School of Medicine, University of Tokyo,University of Tokyo Hospital
(författare)
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Tomita, NaokiTohoku University
(författare)
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Tsukamoto, Tadashi
(författare)
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Kato, TakashiNational Center for Geriatrics and Gerontology
(författare)
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Yoshiyama, KenjiOsaka University
(författare)
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Kowa, HisatomoKobe university
(författare)
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Iwata, Atsushi
(författare)
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Ihara, Ryoko
(författare)
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Suzuki, KazushiNational Defense Medical College
(författare)
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Kasuga, Kensaku
(författare)
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Ikeuchi, Takeshi
(författare)
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Ishii, Kenji
(författare)
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Ito, KengoNational Center for Geriatrics and Gerontology
(författare)
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Nakamura, AkinoriNational Center for Geriatrics and Gerontology
(författare)
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Senda, Michio
(författare)
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Day, Theresa A.Eli Lilly and Company
(författare)
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Burnham, Samantha C.Eli Lilly and Company
(författare)
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Iaccarino, LeonardoEli Lilly and Company
(författare)
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Pontecorvo, Michael J.Eli Lilly and Company
(författare)
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Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital,University of Tokyo Hospital(Swepub:lu)mphy-ohn
(författare)
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Iwatsubo, TakeshiGraduate School of Medicine, University of Tokyo,University of Tokyo Hospital
(författare)
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University of Tokyo HospitalKlinisk minnesforskning
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Alzheimer's Research and Therapy16:11758-9193
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Till lärosätets databas
- Av författaren/redakt...
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Niimi, Yoshiki
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Janelidze, Shore ...
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Sato, Kenichiro
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Tomita, Naoki
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Tsukamoto, Tadas ...
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Kato, Takashi
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visa fler...
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Yoshiyama, Kenji
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Kowa, Hisatomo
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Iwata, Atsushi
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Ihara, Ryoko
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Suzuki, Kazushi
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Kasuga, Kensaku
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Ikeuchi, Takeshi
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Ishii, Kenji
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Ito, Kengo
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Nakamura, Akinor ...
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Senda, Michio
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Day, Theresa A.
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Burnham, Samanth ...
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Iaccarino, Leona ...
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Pontecorvo, Mich ...
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Hansson, Oskar
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Iwatsubo, Takesh ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Alzheimer's Rese ...
- Av lärosätet
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Lunds universitet