Haplotype-based analysis of common variation in the acetyl-CoA carboxyiase alpha gene and breast cancer risk: A case-control study nested within the European prospective investigation into cancer and nutrition

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: onr:"swepub:oai:lup.lub.lu.se:1b16a995-f901-4e8b-a428-207da98519e1" > Haplotype-based ana...

1 av 1
Föregående post
Nästa post
Till träfflistan

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		05025naa a2200877 4500
001		oai:lup.lub.lu.se:1b16a995-f901-4e8b-a428-207da98519e1
003		SwePub
008		160401s2007 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/6698832 URI
024	7	a https://doi.org/10.1158/1055-9965.EPI-06-06172 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Sinilnikova, Olga M.4 aut
245	1 0	a Haplotype-based analysis of common variation in the acetyl-CoA carboxyiase alpha gene and breast cancer risk: A case-control study nested within the European prospective investigation into cancer and nutrition
264	1	c 2007
520		a A key fatty acid synthesis enzyme, acetyl-CoA carboxylase alpha(ACC-alpha), has been shown to be highly expressed in human breast cancer and other tumor types and also to specifically interact with the protein coded by one of two major breast cancer susceptibility genes BRCA1. We used a comprehensive haplotype analysis to examine the contribution of the ACC-alpha common genetic variation (allele frequency > 5%) to breast cancer in a case-control study (1,588 cases/2,600 controls) nested within the European Prospective Investigation into Cancer and Nutrition. We identified 21 haplotypetagging polymorphisms efficiently capturing common variation within 325 kb of ACC-alpha and surrounding sequences using genotype data from the HapMap project and our resequencing data. We found an effect on overall risk of breast cancer in homozygous carriers of one common haplotype [odds ratio (OR), 1.74; 95% confidence interval (95% CI), 1.03-2.94]. When the data were subdivided by menopausal status, we found statistical evidence of heterogeneity for two other common haplotypes (P value for heterogeneity = 0.016 and 0.045). In premenopausal women, the carriers of these haplotypes, compared with noncarriers, had an altered risk of breast cancer (OR, 0.70; 95% CI, 0.53-0.92 and OR, 1.35; 95% CI, 1.04-1.76). These findings were not significant after adjustment for multiple testing and therefore should be considered as preliminary and evaluated in larger independent studies. However, they suggest a possible role of the ACC-alpha common sequence variants in susceptibility to breast cancer and encourage studies of other genes involved in fatty acid synthesis.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700	1	a McKay, James D.4 aut
700	1	a Tavtigian, Sean V.4 aut
700	1	a Canzian, Federico4 aut
700	1	a DeSilva, Deepika4 aut
700	1	a Biessy, Carine4 aut
700	1	a Monnier, Stephanie4 aut
700	1	a Dossus, Laure4 aut
700	1	a Boillot, Catherine4 aut
700	1	a Gioia, Lydie4 aut
700	1	a Hughes, David J.4 aut
700	1	a Jensen, Majken K.4 aut
700	1	a Overvad, Kim4 aut
700	1	a Tjonneland, Anne4 aut
700	1	a Olsen, Anja4 aut
700	1	a Clavel-Chapelon, Francoise4 aut
700	1	a Chajes, Veronique4 aut
700	1	a Joulin, Virginie4 aut
700	1	a Linseisen, Jakob4 aut
700	1	a Chang-Claude, Jenny4 aut
700	1	a Boeing, Heiner4 aut
700	1	a Dahm, Stephan4 aut
700	1	a Trichopoulou, Antonia4 aut
700	1	a Trichopoulos, Dimitrios4 aut
700	1	a Koliva, Maria4 aut
700	1	a Khaw, Kay-Tee4 aut
700	1	a Bingham, Sheila4 aut
700	1	a Allen, Naomi E.4 aut
700	1	a Key, Timothy4 aut
700	1	a Palli, Domenico4 aut
700	1	a Panico, Salvatore4 aut
700	1	a Berrino, Franco4 aut
700	1	a Tumino, Rosario4 aut
700	1	a Vineis, Paolo4 aut
700	1	a Bueno-de-Mesquita, H. Bas4 aut
700	1	a Peeters, Petra H.4 aut
700	1	a van Gils, Carla H.4 aut
700	1	a Lund, Eiliv4 aut
700	1	a Pera, Guillem4 aut
700	1	a Quiros, Jose Ramon4 aut
700	1	a Dorronsoro, Miren4 aut
700	1	a Martinez Garcia, Carmen4 aut
700	1	a Tormo, Maria-Jose4 aut
700	1	a Ardanaz, Eva4 aut
700	1	a Hallmans, Goran4 aut
700	1	a Lenner, Per4 aut
700	1	a Berglund, Goran4 aut
700	1	a Manjer, Jonasu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)smi-jma
700	1	a Riboli, Elio4 aut
700	1	a Lenoir, Gilbert M.4 aut
700	1	a Kaaks, Rudolf4 aut
710	2	a Kirurgib Forskargrupper vid Lunds universitet4 org
773	0	t Cancer Epidemiology Biomarkers & Preventiong 16:3, s. 409-415q 16:3<409-415x 1538-7755
856	4	u http://dx.doi.org/10.1158/1055-9965.EPI-06-0617x freey FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/669883
856	4 8	u https://doi.org/10.1158/1055-9965.EPI-06-0617

Hitta via bibliotek

Cancer Epidemiology Biomarkers & Prevention (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

1 av 1
Föregående post
Nästa post
Till träfflistan

Hitta mer i SwePub

Av författaren/redakt...: Sinilnikova, Olg ...; McKay, James D.; Tavtigian, Sean ...; Canzian, Federic ...; DeSilva, Deepika; Biessy, Carine; visa fler...; Monnier, Stephan ...; Dossus, Laure; Boillot, Catheri ...; Gioia, Lydie; Hughes, David J.; Jensen, Majken K ...; Overvad, Kim; Tjonneland, Anne; Olsen, Anja; Clavel-Chapelon, ...; Chajes, Veroniqu ...; Joulin, Virginie; Linseisen, Jakob; Chang-Claude, Je ...; Boeing, Heiner; Dahm, Stephan; Trichopoulou, An ...; Trichopoulos, Di ...; Koliva, Maria; Khaw, Kay-Tee; Bingham, Sheila; Allen, Naomi E.; Key, Timothy; Palli, Domenico; Panico, Salvator ...; Berrino, Franco; Tumino, Rosario; Vineis, Paolo; Bueno-de-Mesquit ...; Peeters, Petra H ...; van Gils, Carla ...; Lund, Eiliv; Pera, Guillem; Quiros, Jose Ram ...; Dorronsoro, Mire ...; Martinez Garcia, ...; Tormo, Maria-Jos ...; Ardanaz, Eva; Hallmans, Goran; Lenner, Per; Berglund, Goran; Manjer, Jonas; Riboli, Elio; Lenoir, Gilbert ...; Kaaks, Rudolf; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Artiklar i publikationen: Cancer Epidemiol ...

Av lärosätet: Lunds universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se