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Use of selective fa...
Use of selective factor V Leiden screening in pregnancy to identify candidates for anticoagulants.
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- Lindqvist, Pelle (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Olofsson, Per (författare)
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Dahlbäck, Björn (författare)
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(creator_code:org_t)
- 2002
- 2002
- Engelska.
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Ingår i: Obstetrics and Gynecology. - 1873-233X. ; 100:2, s. 332-336
- Relaterad länk:
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To improve identification of gravidas at risk for thrombosis. Venous thromboembolic complications are a major cause of maternal mortality during pregnancy. Factor V Leiden, which causes activated protein C resistance, is the most prevalent thrombophilia in white populations. However, selective screening for factor V Leiden has not been evaluated previously for identifying women who might benefit from anticoagulant prophylaxis during pregnancy. METHODS: We constructed a risk score based on major risk factors such as overweight, family history of thrombosis, previous thrombosis, cesarean delivery, and preeclampsia. A cohort of 2384 women with known factor V Leiden status was studied. Using the risk score and its distribution, we explored possible strategies of doing selective testing for factor V Leiden and their consequences. RESULTS: During the postpartum period, but not antepartum, there is a possibility of identifying women at similar risk as those with a history of thrombosis. Women with a risk score of 2 (4% of women, 0.2% risk of thrombosis) would be screened for factor V Leiden, and those with a resulting risk score of at least 3 (ie, 1.2% risk of thrombosis) would be treated for 6 weeks. Theoretically, for every 83 women treated at this risk level, one thrombotic episode might be prevented. CONCLUSION: By using a risk score, a subgroup of women who could benefit from selective factor V Leiden screening were identified postpartum.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Mass Screening
- Predictive Value of Tests
- Prenatal Care
- Pregnancy
- Prenatal Diagnosis : methods
- Primary Prevention : methods
- Reference Values
- Risk Assessment
- Thrombosis : prevention & control
- Thrombosis : blood
- Sweden
- Non-U.S. Gov't
- Support
- Risk Factors
- Sensitivity and Specificity
- Female
- Human
- Factor V : analysis
- Adult
- Anticoagulants : administration & dosage
- Biological Markers : blood
- Cohort Studies
- Comparative Study
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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