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Bariatric surgery e...
Bariatric surgery enhances splanchnic vascular responses in patients with type 2 diabetes
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- Honka, Henri (författare)
- Turku PET Centre
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- Koffert, Jukka (författare)
- Turunmaa Hospital,Turku PET Centre
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- Kauhanen, Saila (författare)
- Turku University Hospital
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- Teuho, Jarmo (författare)
- Turku PET Centre
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- Hurme, Saija (författare)
- University of Turku
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- Mari, Andrea (författare)
- CNR: National Research Council of Italy
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- Lindqvist, Andreas (författare)
- Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Neuroendokrin cellbiologi,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Neuroendocrine Cell Biology
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- Wierup, Nils (författare)
- Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Neuroendokrin cellbiologi,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Department of Experimental Medical Science,Faculty of Medicine,Neuroendocrine Cell Biology
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- Groop, Leif (författare)
- Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Genomik, diabetes och endokrinologi,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Genomics, Diabetes and Endocrinology
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- Nuutila, Pirjo (författare)
- Turku PET Centre,Turku University Hospital
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(creator_code:org_t)
- 2017-01-17
- 2017
- Engelska 6 s.
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 66:4, s. 880-885
- Relaterad länk:
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http://dx.doi.org/10...
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https://diabetes.dia...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- Bariatric surgery results in notable weight loss and alleviates hyperglycemia in patients with type 2 diabetes (T2D). We aimed to characterize the vascular effects of a mixedmeal and infusion of exogenous glucose-dependent insulinotropic polypeptide (GIP) in the splanchnic region in 10 obese patients with T2D before and after bariatric surgery and in 10 lean control subjects. The experiments were carried out on two separate days. Pancreatic and intestinal blood flow (BF) were measured at baseline, 20 min, and 50 min with 15O-water by using positron emission tomography and MRI. Before surgery, pancreatic and intestinal BF responses to a mixed meal did not differ between obese and lean control subjects. Compared with presurgery, the mixed meal induced a greater increase in plasma glucose, insulin, and GIP concentrations after surgery, which was accompanied by a marked augmentation of pancreatic and intestinal BF responses. GIP infusion decreased pancreatic but increased small intestinal BF similarly in all groups both before and after surgery. Taken together, these results demonstrate that bariatric surgery leads to enhanced splanchnic vascular responses as a likely consequence of rapid glucose appearance and GIP hypersecretion.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (ämneskategori)
- ref (ämneskategori)
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Diabetes
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- Av författaren/redakt...
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Honka, Henri
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Koffert, Jukka
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Kauhanen, Saila
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Teuho, Jarmo
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Hurme, Saija
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Mari, Andrea
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visa fler...
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Lindqvist, Andre ...
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Wierup, Nils
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Groop, Leif
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Nuutila, Pirjo
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Diabetes
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Lunds universitet