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Sökning: onr:"swepub:oai:lup.lub.lu.se:1e0aab87-e13a-47c4-b51b-13a4009f4a5f" > The LKB1-salt-induc...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003530naa a2200541 4500
001oai:lup.lub.lu.se:1e0aab87-e13a-47c4-b51b-13a4009f4a5f
003SwePub
008160401s2014 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/46156222 URI
0247 a https://doi.org/10.1038/ncomms55352 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Patel, Kashyap4 aut
2451 0a The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver.
264 c 2014-08-04
264 1b Springer Science and Business Media LLC,c 2014
338 a electronic2 rdacarrier
520 a LKB1 is a master kinase that regulates metabolism and growth through adenosine monophosphate-activated protein kinase (AMPK) and 12 other closely related kinases. Liver-specific ablation of LKB1 causes increased glucose production in hepatocytes in vitro and hyperglycaemia in fasting mice in vivo. Here we report that the salt-inducible kinases (SIK1, 2 and 3), members of the AMPK-related kinase family, play a key role as gluconeogenic suppressors downstream of LKB1 in the liver. The selective SIK inhibitor HG-9-91-01 promotes dephosphorylation of transcriptional co-activators CRTC2/3 resulting in enhanced gluconeogenic gene expression and glucose production in hepatocytes, an effect that is abolished when an HG-9-91-01-insensitive mutant SIK is introduced or LKB1 is ablated. Although SIK2 was proposed as a key regulator of insulin-mediated suppression of gluconeogenesis, we provide genetic evidence that liver-specific ablation of SIK2 alone has no effect on gluconeogenesis and insulin does not modulate SIK2 phosphorylation or activity. Collectively, we demonstrate that the LKB1-SIK pathway functions as a key gluconeogenic gatekeeper in the liver.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Foretz, Marc4 aut
7001 a Marion, Allison4 aut
7001 a Campbell, David G4 aut
7001 a Gourlay, Robert4 aut
7001 a Boudaba, Nadia4 aut
7001 a Tournier, Emilie4 aut
7001 a Titchenell, Paul4 aut
7001 a Peggie, Mark4 aut
7001 a Deak, Maria4 aut
7001 a Wan, Min4 aut
7001 a Kaestner, Klaus H4 aut
7001 a Göransson, Olgau Lund University,Lunds universitet,Proteinfosforylering,Forskargrupper vid Lunds universitet,Protein Phosphorylation,Lund University Research Groups4 aut0 (Swepub:lu)medk-ogo
7001 a Viollet, Benoit4 aut
7001 a Gray, Nathanael S4 aut
7001 a Birnbaum, Morris J4 aut
7001 a Sutherland, Calum4 aut
7001 a Sakamoto, Kei4 aut
7102 a Proteinfosforyleringb Forskargrupper vid Lunds universitet4 org
7730 t Nature Communicationsd : Springer Science and Business Media LLCg 5:Aug 4q 5:Aug 4x 2041-1723
8564 u https://portal.research.lu.se/files/4288635/7864277x primaryx freey FULLTEXT
8564 u http://www.ncbi.nlm.nih.gov/pubmed/25088745?dopt=Abstractx freey FULLTEXT
8564 u http://dx.doi.org/10.1038/ncomms5535x freey FULLTEXT
8564 u https://www.nature.com/articles/ncomms5535.pdf
8564 8u https://lup.lub.lu.se/record/4615622
8564 8u https://doi.org/10.1038/ncomms5535

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