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Usefulness of Serum...
Usefulness of Serum B-Type Natriuretic Peptide Levels in Comatose Patients Resuscitated from Out-of-Hospital Cardiac Arrest to Predict Outcome
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- Frydland, Martin (författare)
- Copenhagen University Hospital
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- Kjaergaard, Jesper (författare)
- Copenhagen University Hospital
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- Erlinge, David (författare)
- Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital
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- Stammet, Pascal (författare)
- Centre Hospitalier de Luxembourg
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- Nielsen, Niklas (författare)
- Helsingborg Hospital
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- Wanscher, Michael (författare)
- Copenhagen University Hospital
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- Pellis, Tommaso (författare)
- Santa Maria degli Angeli Hospital
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- Friberg, Hans (författare)
- Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups
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- Hovdenes, Jan (författare)
- Oslo university hospital
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- Horn, Janneke (författare)
- Academic Medical Center of University of Amsterdam (AMC)
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- Wetterslev, Jørn (författare)
- Copenhagen University Hospital
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- Thomsen, Jakob H. (författare)
- Copenhagen University Hospital
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- Bro-Jeppesen, John (författare)
- Copenhagen University Hospital
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- Winther-Jensen, Matilde (författare)
- Copenhagen University Hospital
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- Wise, Matthew P. (författare)
- University Hospital of Wales
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- Kuiper, Michael (författare)
- Medical Center Leeuwarden
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- Cronberg, Tobias (författare)
- Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups
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- Gasche, Yvan (författare)
- Geneva University Hospital
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- Devaux, Yvan (författare)
- Luxembourg Institute of Health
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- Åneman, Anders (författare)
- University of New South Wales
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- Hassager, Christian (författare)
- Copenhagen University Hospital
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska 8 s.
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Ingår i: American Journal of Cardiology. - : Elsevier BV. - 0002-9149. ; 118:7, s. 998-1005
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- N-terminal pro-B-type natriuretic (NT-proBNP) is expressed in the heart and brain, and serum levels are elevated in acute heart and brain diseases. We aimed to assess the possible association between serum levels and neurological outcome and death in comatose patients resuscitated from out-of-hospital cardiac arrest (OHCA). Of the 939 comatose OHCA patients enrolled and randomized in the Targeted Temperature Management (TTM) trial to TTM at 33°C or 36°C for 24 hours, 700 were included in the biomarker substudy. Of these, 647 (92%) had serum levels of NT-proBNP measured 24, 48, and 72 hours after return of spontaneous circulation (ROSC). Neurological outcome was evaluated by the Cerebral Performance Category (CPC) score and modified Rankin Scale (mRS) at 6 months. Six hundred thirty-eight patients (99%) had serum NT-proBNP levels ≥125 pg/ml. Patients with TTM at 33°C had significantly lower NT-proBNP serum levels (median 1,472 pg/ml) than those in the 36°C group (1,914 pg/ml) at 24 hours after ROSC, p <0.01 but not at 48 and 72 hours. At 24 hours, an increase in NT-proBNP quartile was associated with death (Plogrank <0.0001). In addition, NT-proBNP serum levels > median were independently associated with poor neurological outcome (odds ratio, ORCPC 2.02, CI 1.34 to 3.05, p <0.001; ORmRS 2.28, CI 1.50 to 3.46, p <0.001) adjusted for potential confounders. The association was diminished at 48 and 72 hours after ROSC. In conclusion, NT-proBNP serum levels are increased in comatose OHCA patients. Furthermore, serum NT-proBNP levels are affected by level of TTM and are associated with death and poor neurological outcome.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Frydland, Martin
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Kjaergaard, Jesp ...
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Erlinge, David
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Stammet, Pascal
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Nielsen, Niklas
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Wanscher, Michae ...
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visa fler...
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Pellis, Tommaso
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Friberg, Hans
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Hovdenes, Jan
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Horn, Janneke
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Wetterslev, Jørn
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Thomsen, Jakob H ...
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Bro-Jeppesen, Jo ...
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Winther-Jensen, ...
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Wise, Matthew P.
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Kuiper, Michael
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Cronberg, Tobias
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Gasche, Yvan
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Devaux, Yvan
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Åneman, Anders
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Hassager, Christ ...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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och Kardiologi
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American Journal ...
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Lunds universitet