Sökning: onr:"swepub:oai:lup.lub.lu.se:20d7ddf7-6757-4e92-aafa-dd04717edde5" > The genomic landsca...
Fältnamn | Indikatorer | Metadata |
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000 | 04578naa a2200889 4500 | |
001 | oai:lup.lub.lu.se:20d7ddf7-6757-4e92-aafa-dd04717edde5 | |
003 | SwePub | |
008 | 161123s2016 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/20d7ddf7-6757-4e92-aafa-dd04717edde52 URI |
024 | 7 | a https://doi.org/10.1038/ng.37092 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Faber, Zachary J4 aut |
245 | 1 0 | a The genomic landscape of core-binding factor acute myeloid leukemias |
264 | c 2016-10-31 | |
264 | 1 | b Springer Science and Business Media LLC,c 2016 |
300 | a 6 s. | |
520 | a Acute myeloid leukemia (AML) comprises a heterogeneous group of leukemias frequently defined by recurrent cytogenetic abnormalities, including rearrangements involving the core-binding factor (CBF) transcriptional complex. To better understand the genomic landscape of CBF-AMLs, we analyzed both pediatric (n = 87) and adult (n = 78) samples, including cases with RUNX1-RUNX1T1 (n = 85) or CBFB-MYH11 (n = 80) rearrangements, by whole-genome or whole-exome sequencing. In addition to known mutations in the Ras pathway, we identified recurrent stabilizing mutations in CCND2, suggesting a previously unappreciated cooperating pathway in CBF-AML. Outside of signaling alterations, RUNX1-RUNX1T1 and CBFB-MYH11 AMLs demonstrated remarkably different spectra of cooperating mutations, as RUNX1-RUNX1T1 cases harbored recurrent mutations in DHX15 and ZBTB7A, as well as an enrichment of mutations in epigenetic regulators, including ASXL2 and the cohesin complex. This detailed analysis provides insights into the pathogenesis and development of CBF-AML, while highlighting dramatic differences in the landscapes of cooperating mutations for these related AML subtypes. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng |
700 | 1 | a Chen, Xiang4 aut |
700 | 1 | a Gedman, Amanda Larson4 aut |
700 | 1 | a Boggs, Kristy4 aut |
700 | 1 | a Cheng, Jinjun4 aut |
700 | 1 | a Ma, Jing4 aut |
700 | 1 | a Radtke, Ina4 aut |
700 | 1 | a Chao, Jyh-Rong4 aut |
700 | 1 | a Walsh, Michael P4 aut |
700 | 1 | a Song, Guangchun4 aut |
700 | 1 | a Andersson, Anna Ku Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,St Jude Children´s Research Hospital, Memphis4 aut0 (Swepub:lu)kgen-aan |
700 | 1 | a Dang, Jinjun4 aut |
700 | 1 | a Dong, Li4 aut |
700 | 1 | a Liu, Yu4 aut |
700 | 1 | a Huether, Robert4 aut |
700 | 1 | a Cai, Zhongling4 aut |
700 | 1 | a Mulder, Heather4 aut |
700 | 1 | a Wu, Gang4 aut |
700 | 1 | a Edmonson, Michael4 aut |
700 | 1 | a Rusch, Michael4 aut |
700 | 1 | a Qu, Chunxu4 aut |
700 | 1 | a Li, Yongjin4 aut |
700 | 1 | a Vadodaria, Bhavin4 aut |
700 | 1 | a Wang, Jianmin4 aut |
700 | 1 | a Hedlund, Erin4 aut |
700 | 1 | a Cao, Xueyuan4 aut |
700 | 1 | a Yergeau, Donald4 aut |
700 | 1 | a Nakitandwe, Joy4 aut |
700 | 1 | a Pounds, Stanley B4 aut |
700 | 1 | a Shurtleff, Sheila4 aut |
700 | 1 | a Fulton, Robert S4 aut |
700 | 1 | a Fulton, Lucinda L4 aut |
700 | 1 | a Easton, John4 aut |
700 | 1 | a Parganas, Evan4 aut |
700 | 1 | a Pui, Ching-Hon4 aut |
700 | 1 | a Rubnitz, Jeffrey E4 aut |
700 | 1 | a Ding, Li4 aut |
700 | 1 | a Mardis, Elaine R4 aut |
700 | 1 | a Wilson, Richard K4 aut |
700 | 1 | a Gruber, Tanja A4 aut |
700 | 1 | a Mullighan, Charles G4 aut |
700 | 1 | a Schlenk, Richard F4 aut |
700 | 1 | a Paschka, Peter4 aut |
700 | 1 | a Döhner, Konstanze4 aut |
700 | 1 | a Döhner, Hartmut4 aut |
700 | 1 | a Bullinger, Lars4 aut |
700 | 1 | a Zhang, Jinghui4 aut |
700 | 1 | a Klco, Jeffery M4 aut |
700 | 1 | a Downing, James R4 aut |
710 | 2 | a Avdelningen för klinisk genetikb Institutionen för laboratoriemedicin4 org |
773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 48, s. 1551-1556q 48<1551-1556x 1546-1718x 1061-4036 |
856 | 4 | u http://dx.doi.org/10.1038/ng.3709y FULLTEXT |
856 | 4 | u https://europepmc.org/articles/pmc5508996?pdf=render |
856 | 4 8 | u https://lup.lub.lu.se/record/20d7ddf7-6757-4e92-aafa-dd04717edde5 |
856 | 4 8 | u https://doi.org/10.1038/ng.3709 |
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