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Prognostic Signific...
Prognostic Significance of Chest Imaging by LUS and CT in COVID-19 Inpatients : The ECOVID Multicenter Study
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- Tana, Claudio (författare)
- Ss Annunziata Hospital
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- Ricci, Fabrizio (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Casa di Cura Villa Serena di Città Sant'Angelo,University G.d'Annunzio of Chieti-Pescara
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- Coppola, Maria Gabriella (författare)
- Ospedale del Mare
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- Mantini, Cesare (författare)
- University G.d'Annunzio of Chieti-Pescara
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- Lauretani, Fulvio (författare)
- University of Parma,Parma University Hospital
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- Campanozzi, Daniele (författare)
- San Salvatore Hospital
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- Renda, Giulia (författare)
- University G.d'Annunzio of Chieti-Pescara
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- Gallina, Sabina (författare)
- University G.d'Annunzio of Chieti-Pescara
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- Lugará, Marina (författare)
- Ospedale del Mare
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- Cipollone, Francesco (författare)
- University G.d'Annunzio of Chieti-Pescara
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- Giamberardino, Maria Adele (författare)
- University G.d'Annunzio of Chieti-Pescara
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- Mucci, Luciano (författare)
- San Salvatore Hospital
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(creator_code:org_t)
- 2021-08-31
- 2022
- Engelska.
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Ingår i: Respiration. - : S. Karger AG. - 0025-7931 .- 1423-0356. ; 101:2, s. 122-131
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.karger.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Point-of-care lung ultrasound (LUS) score is a semiquantitative score of lung damage severity. High-resolution computed tomography (HRCT) is the gold standard method to evaluate the severity of lung involvement from the novel coronavirus disease (COVID-19). Few studies have investigated the clinical significance of LUS and HRCT scores in patients with COVID-19. Therefore, the aim of this study was to evaluate the prognostic yield of LUS and of HRCT in COVID-19 patients. Methods: We carried out a multicenter, retrospective study aimed at evaluating the prognostic yield of LUS and HRCT by exploring the survival curve of COVID-19 inpatients. LUS and chest CT scores were calculated retrospectively by 2 radiologists with >10 years of experience in chest imaging, and the decisions were reached in consensus. LUS score was calculated on the basis of the presence or not of pleural line abnormalities, B-lines, and lung consolidations. The total score (range 0-36) was obtained from the sum of the highest scores obtained in each region. CT score was calculated for each of the 5 lobes considering the anatomical extension according to the percentage parenchymal involvement. The resulting overall global semiquantitative CT score was the sum of each single lobar score and ranged from 0 (no involvement) to 25 (maximum involvement). Results: One hundred fifty-three COVID-19 inpatients (mean age 65 ± 15 years; 65% M), including 23 (15%) in-hospital deaths for any cause over a mean follow-up of 14 days were included. Mean LUS and CT scores were 19 ± 12 and 10 ± 7, respectively. A strong positive linear correlation between LUS and CT scores (Pearson correlation r = 0.754; R = 0.568; p < 0.001) was observed. By ROC curve analysis, the optimal cut-point for mortality prediction was 20 for LUS score and 4.5 for chest CT score. According to Kaplan-Meier survival analysis, in-hospital mortality significantly increased among COVID-19 patients presenting with an LUS score ≥20 (log-rank 0.003; HR 9.87, 95% CI: 2.22-43.83) or a chest CT score ≥4.5 (HR 4.34, 95% CI: 0.97-19.41). At multivariate Cox regression analysis, LUS score was the sole independent predictor of in-hospital mortality yielding an adjusted HR of 7.42 (95% CI: 1.59-34.5). Conclusion: LUS score is useful to stratify the risk in COVID-19 patients, predicting those that are at high risk of mortality.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Tana, Claudio
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Ricci, Fabrizio
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Coppola, Maria G ...
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Mantini, Cesare
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Lauretani, Fulvi ...
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Campanozzi, Dani ...
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visa fler...
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Renda, Giulia
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Gallina, Sabina
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Lugará, Marina
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Cipollone, Franc ...
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Giamberardino, M ...
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Mucci, Luciano
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Anestesi och int ...
- Artiklar i publikationen
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Respiration
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Lunds universitet