onr:"swepub:oai:lup.lub.lu.se:22310d4c-ff85-48a7-bcea-a834cc2f7641"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04482naa a2200373 4500 | |
| 001 | oai:lup.lub.lu.se:22310d4c-ff85-48a7-bcea-a834cc2f7641 | |
| 003 | SwePub | |
| 008 | 160404s2009 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/14700462 URI |
| 024 | 7 | a https://doi.org/10.1186/1741-7015-7-392 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Tofik, Rafidu Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-rtf |
| 245 | 1 0 | a Increased urine IgM excretion predicts cardiovascular events in patients with type 1 diabetes nephropathy. |
| 264 | c 2009-08-04 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2009 |
| 520 | a BACKGROUND: Diabetic nephropathy, a major complication of diabetes, is characterized by progressive renal injury and increased cardiovascular mortality. An increased urinary albumin excretion due dysfunction of the glomerular barrier is an early sign of diabetic nephropathy. An increased urinary excretion of higher molecular weight proteins such as IgM appears with progression of glomerular injury. We aim here to study the prognostic significance of urine IgM excretion in patients with type 1 diabetes mellitus (type 1 diabetic nephropathy). METHODS: This is an observational study of 139 patients with type 1 diabetes mellitus (79 males and 60 females) under routine care at the diabetic outpatient clinic at the Lund University Hospital. The median follow-up time was 18 years (1 to 22) years. Urine albumin and urine IgM concentration were measured at time of recruitment. RESULTS: Overall 32 (14 male and 18 female) patients died in a cardiovascular event and 20 (11 male and 9 female) patients reached end-stage renal disease. Univariate analysis indicated that patient survival and renal survival were inversely associated with urine albumin excretion (RR = 2.9 and 5.8, respectively) and urine IgM excretion (RR = 4.6 and 5.7, respectively). Stratified analysis demonstrated that in patients with different degrees of albuminuria, the cardiovascular mortality rate and the incidence of end-stage renal disease was approximately three times higher in patients with increased urine IgM excretion. CONCLUSION: An increase in urinary IgM excretion in patients with type 1 diabetes is associated with an increased risk for cardiovascular mortality and renal failure, regardless of the degree of albuminuria. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng |
| 700 | 1 | a Torffvit, Oleu Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Njurmedicin,Institutionen för kliniska vetenskaper, Lund,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Nephrology,Department of Clinical Sciences, Lund4 aut0 (Swepub:lu)med-oto |
| 700 | 1 | a Rippe, Bengtu Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)njur-bri |
| 700 | 1 | a Bakoush, Omranu Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)njur-oba |
| 710 | 2 | a Njurmedicinb Sektion II4 org |
| 773 | 0 | t BMC Medicined : Springer Science and Business Media LLCg 7:Aug 4q 7:Aug 4x 1741-7015 |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/19653885?dopt=Abstracty FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1186/1741-7015-7-39y FULLTEXT |
| 856 | 4 | u https://bmcmedicine.biomedcentral.com/track/pdf/10.1186/1741-7015-7-39 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1470046 |
| 856 | 4 8 | u https://doi.org/10.1186/1741-7015-7-39 |
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