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Anti-inflammatory e...
Anti-inflammatory effect of oligostilbenoids from Vitis heyneana in LPS-stimulated RAW 264.7 macrophages via suppressing the NF-ΚB activation
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- Ha, Do Thi (författare)
- National Institute of Medicinal Materials, Vietnam
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- Long, Phung Thanh (författare)
- National Institute of Medicinal Materials, Vietnam
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- Hien, Tran Thi (författare)
- Lund University,Lunds universitet,Cancerinfektion,Forskargrupper vid Lunds universitet,Cancer Infection,Lund University Research Groups,Thai Binh University of Medicine and Pharmacy
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- Tuan, Dao Trong (författare)
- University of Copenhagen
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- An, Nguyen Thi Thuy (författare)
- National Institute of Medicinal Materials, Vietnam,Kyungpook National University
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- Khoi, Nguyen Minh (författare)
- National Institute of Medicinal Materials, Vietnam
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- Oanh, Ha (författare)
- Hanoi University of Pharmacy
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- Hung, Tran Manh (författare)
- University of Da Nang
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(creator_code:org_t)
- 2018-02-13
- 2018
- Engelska.
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Ingår i: Chemistry Central Journal. - : Springer Science and Business Media LLC. - 1752-153X. ; 12:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://bmcchem.biom...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Vitis heyneana is widely distributed in the north of Vietnam, it has been used in Vietnamese traditional medicine as an agent for treatment of arthritis, bronchitis, carbuncles and inflammatory conditions, and menstrual irregularities. However, this plant has not been investigated in phytochemical constituents and biological effects, especially in the anti-inflammatory property. Results: Bioassay-guided fractionation of the EtOAc soluble fraction from the aerial part of Vitis heyneana resulted in the isolation of a series of oligostilbenoids as piceid (1), 2-r-viniferin (2), betulifol A (3), vitisinol C (4), (-)-trans-ε-viniferin (5), α-viniferin (6), shoreaketon (7), amurensin B (8), vitisinol B (9), and cis-vitisin B (10). Compound 5 showed the most potent inhibitory activities by suppressing LPS-induced COX-2 expression and PGE2 production. This compound exhibited significantly reduced LPS-induced nitric oxide (NO) release in a dose-dependent manner. These effects are accompanied with the inhibition of transcription factor NF-ΚB activation. Conclusion: The results suggested that trans-ε-viniferin exerts anti-inflammatory effects via suppression the NF-ΚB activation in RAW 264.7 cells. [Figure not available: see fulltext.]
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- (-)-Trans-ε-viniferin
- COX-2
- NF-ΚB
- NO
- PGE2
- Vitis heyneana
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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