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GISCOME – Genetics ...
GISCOME – Genetics of Ischaemic Stroke Functional Outcome network : A protocol for an international multicentre genetic association study
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- Maguire, Jane M. (författare)
- Hunter Medical Research Institute, Australia,University of Newcastle,University of Technology Sydney
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- Bevan, Steve (författare)
- University of Lincoln
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- Stanne, Tara M. (författare)
- Sahlgrenska Academy
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- Lorenzen, Erik (författare)
- Sahlgrenska Academy
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- Fernandez-Cadenas, Israel (författare)
- Mutua De Terrassa Hospital,Vall d'Hebron University Hospital
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- Hankey, Graeme J. (författare)
- University of Western Australia, Crawley
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- Jimenez-Conde, Jordi (författare)
- Hospital del Mar Medical Research Institute
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- Jood, Katarina, 1966 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Lee, Jin Moo (författare)
- Washington University in St. Louis
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- Lemmens, Robin (författare)
- Flanders Interuniversity Institute for Biotechnology,Catholic University of Leuven,University Hospitals Leuven
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- Levi, Christopher (författare)
- Hunter Medical Research Institute, Australia,University of Newcastle
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- Norrving, Bo (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Stroke Research Group,Lund University Research Groups,Skåne University Hospital
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- Rannikmae, Kristiina (författare)
- University of Edinburgh
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- Rost, Natalia (författare)
- Massachusetts General Hospital
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- Rosand, Jonathan (författare)
- Broad Institute,Massachusetts General Hospital
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- Rothwell, Peter M. (författare)
- University of Oxford
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- Scott, Rodney (författare)
- University of Technology Sydney,Hunter Medical Research Institute, Australia
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- Strbian, Daniel (författare)
- Helsinki University Central Hospital
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- Sturm, Jonathan (författare)
- University of Newcastle
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- Sudlow, Cathie (författare)
- University of Edinburgh
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- Traylor, Matthew (författare)
- University of Cambridge
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- Thijs, Vincent (författare)
- University of Melbourne,Austin Health
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- Tatlisumak, Turgut (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Wieloch, Tadeusz (författare)
- Lund University,Lunds universitet,Laboratory for Experimental Brain Research,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Woo, Daniel (författare)
- University of Cincinnati
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- Worrall, Bradford B. (författare)
- University of Virginia
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- Jern, Christina, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Lindgren, Arne (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Stroke Research Group,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- 2017-04-19
- 2017
- Engelska 9 s.
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Ingår i: European Stroke Journal. - : SAGE Publications. - 2396-9873 .- 2396-9881. ; 2:3, s. 229-237
- Relaterad länk:
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http://dx.doi.org/10...
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https://journals.sag...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Introduction: Genome-wide association studies have identified several novel genetic loci associated with stroke risk, but how genetic factors influence stroke outcome is less studied. The Genetics of Ischaemic Stroke Functional outcome network aims at performing genetic studies of stroke outcome. We here describe the study protocol and methods basis of Genetics of Ischaemic Stroke Functional outcome. Methods: The Genetics of Ischaemic Stroke Functional outcome network has assembled patients from 12 ischaemic stroke projects with genome-wide genotypic and outcome data from the International Stroke Genetics Consortium and the National Institute of Neurological Diseases Stroke Genetics Network initiatives. We have assessed the availability of baseline variables, outcome metrics and time-points for collection of outcome data. Results: We have collected 8831 ischaemic stroke cases with genotypic and outcome data. Modified Rankin score was the outcome metric most readily available. We detected heterogeneity between cohorts for age and initial stroke severity (according to the NIH Stroke Scale), and will take this into account in analyses. We intend to conduct a first phase genome-wide association outcome study on ischaemic stroke cases with data on initial stroke severity and modified Rankin score within 60–190 days. To date, we have assembled 5762 such cases and are currently seeking additional cases meeting these criteria for second phase analyses. Conclusion: Genetics of Ischaemic Stroke Functional outcome is a unique collection of ischaemic stroke cases with detailed genetic and outcome data providing an opportunity for discovery of genetic loci influencing functional outcome. Genetics of Ischaemic Stroke Functional outcome will serve as an exploratory study where the results as well as the methodological observations will provide a basis for future studies on functional outcome. Genetics of Ischaemic Stroke Functional outcome can also be used for candidate gene replication or assessing stroke outcome non-genetic association hypotheses.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- functional outcome
- Genetic association studies
- stroke
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Maguire, Jane M.
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Bevan, Steve
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Stanne, Tara M.
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Lorenzen, Erik
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Fernandez-Cadena ...
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Hankey, Graeme J ...
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visa fler...
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Jimenez-Conde, J ...
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Jood, Katarina, ...
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Lee, Jin Moo
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Lemmens, Robin
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Levi, Christophe ...
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Norrving, Bo
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Rannikmae, Krist ...
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Rost, Natalia
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Rosand, Jonathan
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Rothwell, Peter ...
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Scott, Rodney
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Strbian, Daniel
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Sturm, Jonathan
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Sudlow, Cathie
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Traylor, Matthew
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Thijs, Vincent
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Tatlisumak, Turg ...
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Wieloch, Tadeusz
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Woo, Daniel
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Worrall, Bradfor ...
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Jern, Christina, ...
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Lindgren, Arne
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Medicinsk geneti ...
- Artiklar i publikationen
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European Stroke ...
- Av lärosätet
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Lunds universitet
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Göteborgs universitet