Sökning: onr:"swepub:oai:lup.lub.lu.se:25ec96d3-0334-48a4-a788-b6802c0d10f7" > Deficiency or inhib...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03299naa a2200469 4500 | |
001 | oai:lup.lub.lu.se:25ec96d3-0334-48a4-a788-b6802c0d10f7 | |
003 | SwePub | |
008 | 160401s2001 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/1313452 URI |
024 | 7 | a https://doi.org/10.1038/846672 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Angelillo-Scherrer, Anne4 aut |
245 | 1 0 | a Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis |
264 | c 2001-02-01 | |
264 | 1 | b Springer Science and Business Media LLC,c 2001 |
338 | a electronic2 rdacarrier | |
520 | a The growth arrest-specific gene 6 product (Gas6) is a secreted protein related to the anticoagulant protein S but its role in hemostasis is unknown. Here we show that inactivation of the Gas6 gene prevented venous and arterial thrombosis in mice, and protected against fatal collagen/epinephrine-induced thrombo embolism. Gas6-/- mice did not, however, suffer spontaneous bleeding and had normal bleeding after tail clipping. In addition, we found that Gas6 antibodies inhibited platelet aggregation in vitro and protected mice against fatal thrombo embolism without causing bleeding in vivo. Gas6 amplified platelet aggregation and secretion in response to known agonists. Platelet dysfunction in Gas6-/- mice resembled that of patients with platelet signaling transduction defects. Thus, Gas6 is a platelet-response amplifier that plays a significant role in thrombosis. These findings warrant further evaluation of the possible therapeutic use of Gas6 inhibition for prevention of thrombosis. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Läkemedelskemi0 (SwePub)301032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medicinal Chemistry0 (SwePub)301032 hsv//eng |
700 | 1 | a Garcia de Frutos, Pablou Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)klke-pga |
700 | 1 | a Aparicio, Cristina4 aut |
700 | 1 | a Melis, Els4 aut |
700 | 1 | a Savi, Pierre4 aut |
700 | 1 | a Lupu, Florea4 aut |
700 | 1 | a Arnout, Jef4 aut |
700 | 1 | a Dewerchin, Mieke4 aut |
700 | 1 | a Hoylaerts, Marc F.4 aut |
700 | 1 | a Herbert, Jean-Marc4 aut |
700 | 1 | a Collen, Désiré4 aut |
700 | 1 | a Dahlbäck, Björnu Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)klke-bda |
700 | 1 | a Carmeliet, Peter4 aut |
710 | 2 | a Klinisk kemi, Malmöb Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Nature Medicined : Springer Science and Business Media LLCg 7:2, s. 215-221q 7:2<215-221x 1546-170Xx 1078-8956 |
856 | 4 | u https://portal.research.lu.se/files/4382960/624199.pdfx primaryx freey FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1038/84667y FULLTEXT |
856 | 4 | u https://lup.lub.lu.se/search/files/4382960/624199.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/131345 |
856 | 4 8 | u https://doi.org/10.1038/84667 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.