Sökning: onr:"swepub:oai:lup.lub.lu.se:26dd769e-7441-41b5-8b35-a9ee3b58942e" > Transcriptional lan...
Fältnamn | Indikatorer | Metadata |
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000 | 06724naa a2200697 4500 | |
001 | oai:lup.lub.lu.se:26dd769e-7441-41b5-8b35-a9ee3b58942e | |
003 | SwePub | |
008 | 190103s2018 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/26dd769e-7441-41b5-8b35-a9ee3b58942e2 URI |
024 | 7 | a https://doi.org/10.1073/pnas.18143971152 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Li, Jian Fengu Shanghai Jiao Tong University,Ruijin Hospital4 aut |
245 | 1 0 | a Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases |
264 | c 2018-11-28 | |
264 | 1 | b Proceedings of the National Academy of Sciences,c 2018 |
520 | a Most B cell precursor acute lymphoblastic leukemia (BCP ALL) can be classified into known major genetic subtypes, while a substantial proportion of BCP ALL remains poorly characterized in relation to its underlying genomic abnormalities. We therefore initiated a large-scale international study to reanalyze and delineate the transcriptome landscape of 1,223 BCP ALL cases using RNA sequencing. Fourteen BCP ALL gene expression subgroups (G1 to G14) were identified. Apart from extending eight previously described subgroups (G1 to G8 associated with MEF2D fusions, TCF3–PBX1 fusions, ETV6–RUNX1–positive/ETV6–RUNX1–like, DUX4 fusions, ZNF384 fusions, BCR–ABL1/Ph–like, high hyperdiploidy, and KMT2A fusions), we defined six additional gene expression subgroups: G9 was associated with both PAX5 and CRLF2 fusions; G10 and G11 with mutations in PAX5 (p.P80R) and IKZF1 (p.N159Y), respectively; G12 with IGH–CEBPE fusion and mutations in ZEB2 (p.H1038R); and G13 and G14 with TCF3/4–HLF and NUTM1 fusions, respectively. In pediatric BCP ALL, subgroups G2 to G5 and G7 (51 to 65/67 chromosomes) were associated with low-risk, G7 (with ≤50 chromosomes) and G9 were intermediate-risk, whereas G1, G6, and G8 were defined as high-risk subgroups. In adult BCP ALL, G1, G2, G6, and G8 were associated with high risk, while G4, G5, and G7 had relatively favorable outcomes. This large-scale transcriptome sequence analysis of BCP ALL revealed distinct molecular subgroups that reflect discrete pathways of BCP ALL, informing disease classification and prognostic stratification. The combined results strongly advocate that RNA sequencing be introduced into the clinical diagnostic workup of BCP ALL. four decades, most of the recurring chromosomal abnormalities, including aneuploidy, chromosomal rearrangements/gene fusions (e.g., ETV6–RUNX1, BCR–ABL1, and TCF3–PBX1), and rearrangements of KMT2A (previously MLL), were identified by. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a BCP ALL | |
653 | a Gene fusion | |
653 | a Gene mutation | |
653 | a RNA-seq | |
653 | a Subtypes | |
700 | 1 | a Dai, Yu Tingu Ruijin Hospital,Shanghai Jiao Tong University4 aut |
700 | 1 | a Lilljebjörn, Henriku Lund University,Lunds universitet,Translationella genomiska och funktionella studier av leukemi,Forskargrupper vid Lunds universitet,Translational Genomic and Functional Studies of Leukemia,Lund University Research Groups4 aut0 (Swepub:lu)tmb-hli |
700 | 1 | a Shen, Shu Hongu Shanghai Children’s Medical Center,Shanghai Jiao Tong University4 aut |
700 | 1 | a Cui, Bo Wenu Shanghai Jiao Tong University,Ruijin Hospital4 aut |
700 | 1 | a Bai, Lingu Ruijin Hospital,Shanghai Jiao Tong University4 aut |
700 | 1 | a Liu, Yuan Fangu Shanghai Jiao Tong University,Ruijin Hospital4 aut |
700 | 1 | a Qian, Mao Xiangu St Jude Children´s Research Hospital, Memphis4 aut |
700 | 1 | a Kubota, Yasuou University of Tokyo4 aut |
700 | 1 | a Kiyoi, Hitoshiu Nagoya University4 aut |
700 | 1 | a Matsumura, Itaruu Kindai University4 aut |
700 | 1 | a Miyazaki, Yasushiu Nagasaki University4 aut |
700 | 1 | a Olsson, Lindau Lund University,Lunds universitet,Genetiska och epigenetiska studier av barnleukemi,Forskargrupper vid Lunds universitet,Genetic and epigenetic studies of pediatric leukemia,Lund University Research Groups4 aut0 (Swepub:lu)med-ldo |
700 | 1 | a Tan, Ah Moyu KK Women’s and Children’s Hospital4 aut |
700 | 1 | a Ariffin, Hanyu University of Malaya4 aut |
700 | 1 | a Chen, Jingu Shanghai Children’s Medical Center,Shanghai Jiao Tong University4 aut |
700 | 1 | a Takita, Junkou Kyoto University4 aut |
700 | 1 | a Yasuda, Takahikou National Hospital Organization, Japan4 aut |
700 | 1 | a Mano, Hiroyukiu National Cancer Center Research Institute, Japan4 aut |
700 | 1 | a Johansson, Bertilu Lund University,Lunds universitet,Genetiska och epigenetiska studier av barnleukemi,Forskargrupper vid Lunds universitet,Genetic and epigenetic studies of pediatric leukemia,Lund University Research Groups,Regional Laboratories Region Skåne4 aut0 (Swepub:lu)kgen-bjo |
700 | 1 | a Yang, Jun J.u St Jude Children´s Research Hospital, Memphis4 aut |
700 | 1 | a Yeoh, Allen Eng Juhu National University of Singapore4 aut |
700 | 1 | a Hayakawa, Fumihikou Nagoya University4 aut |
700 | 1 | a Chen, Zhuu Shanghai Jiao Tong University,Ruijin Hospital4 aut |
700 | 1 | a Pui, Ching Honu St Jude Children´s Research Hospital, Memphis4 aut |
700 | 1 | a Fioretos, Thoasu Lund University,Lunds universitet,Translationella genomiska och funktionella studier av leukemi,Forskargrupper vid Lunds universitet,Translational Genomic and Functional Studies of Leukemia,Lund University Research Groups,Regional Laboratories Region Skåne4 aut0 (Swepub:lu)kgen-tfi |
700 | 1 | a Chen, Sai Juanu Ruijin Hospital,Shanghai Jiao Tong University4 aut |
700 | 1 | a Huang, Jin Yanu Ruijin Hospital,Shanghai Jiao Tong University4 aut |
710 | 2 | a Shanghai Jiao Tong Universityb Ruijin Hospital4 org |
773 | 0 | t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciencesg 115:50, s. 11711-11720q 115:50<11711-11720x 0027-8424 |
773 | 0 | t Proceedings of the National Academy of Sciencesd : Proceedings of the National Academy of Sciencesg 115:50, s. 11711-11720q 115:50<11711-11720x 1091-6490 |
856 | 4 | u http://dx.doi.org/10.1073/pnas.1814397115y FULLTEXT |
856 | 4 | u https://www.pnas.org/content/pnas/115/50/E11711.full.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/26dd769e-7441-41b5-8b35-a9ee3b58942e |
856 | 4 8 | u https://doi.org/10.1073/pnas.1814397115 |
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