Sökning: onr:"swepub:oai:lup.lub.lu.se:27170e46-ea23-4d7b-8836-ce8427fd95cd" >
Linear age-course e...
Linear age-course effects on the associations between body mass index, triglycerides, and female breast and male liver cancer risk : An internal replication study of 800,000 individuals
-
- Häggström, Christel (författare)
- Uppsala universitet,Umeå universitet,Uppsala University,Umeå University,Enheten för biobanksforskning,Näringsforskning,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.,Urologkirurgi,Department of Biobank Research, Umeå University; Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University
-
- Jonsson, Håkan (författare)
- Umeå universitet,Umeå University,Onkologi,Umea Univ, Dept Radiat Sci, Umea, Sweden
-
- Bjørge, Tone (författare)
- Cancer Registry of Norway, Institute of Population-Based Cancer Research,University of Bergen,Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway;Canc Registry Norway, Oslo, Norway
-
visa fler...
-
- Nagel, Gabriele (författare)
- Agency for Preventive and Social Medicine Vorarlberg,University of Ulm,Ulm Univ, Inst Epidemiol & Med Biometry, Ulm, Germany;Agcy Prevent & Social Med, Vorarlberg Canc Registry, Bregenz, Aks, Austria
-
- Manjer, Jonas (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Surg, Malmo, Sweden
-
- Ulmer, Hanno (författare)
- Medical University of Innsbruck,Innsbruck Med Univ, Dept Med Stat Informat & Hlth Econ, Innsbruck, Austria
-
- Drake, Isabel (författare)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups,Lund Univ, Dept Clin Sci Malmo, Lund, Sweden
-
- Ghaderi, Sara (författare)
- University of Bergen,Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway
-
- Lang, Alois (författare)
- Agency for Preventive and Social Medicine Vorarlberg,Agcy Prevent & Social Med, Vorarlberg Canc Registry, Bregenz, Aks, Austria
-
- Engeland, Anders (författare)
- University of Bergen,Norwegian Institute of Public Health,Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway;Norwegian Inst Publ Hlth, Bergen, Norway
-
- Stattin, Pär (författare)
- Uppsala universitet,Umeå universitet,Uppsala University,Urologi och andrologi,Urologkirurgi
-
- Stocks, Tanja (författare)
- Umeå universitet,Lund University,Lunds universitet,Registerbaserad epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Register-based epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Urologi och andrologi,Lund Univ, Dept Clin Sci Lund, Lund, Sweden
-
visa färre...
-
(creator_code:org_t)
- 2019-03-18
- 2020
- Engelska 10 s.
-
Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 146:1, s. 58-67
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://bora.uib.no/...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Apart from the consistently observed differential association between obesity and breast cancer risk by menopausal status, the associations between obesity and other metabolic imbalances with risks of cancers have not been systematically investigated across the age-course. We created two random 50–50% cohorts from six European cohorts comprising 813,927 individuals. In the “discovery cohort”, we used Cox regression with attained age as time-scale and tested interactions between body mass index (BMI), blood pressure, plasma glucose, triglycerides and cholesterol, and attained age in relation to cancer risk. Results with a p-value below 0.05 were additionally tested in the “replication cohort” where a replicated result was considered evidence of a linear interaction with attained age. These findings were investigated by flexible parametric survival models for any age-plateaus in their shape of associations with cancer risk across age. Consistent with other studies, BMI was negatively related to breast cancer risk (n cases = 11,723) among younger (premenopausal) women. However, the association remained negative for several years after menopause and, although gradually weakening over age, the association became positive only at 62 years of age. This linear and positive age-interaction was also found for triglycerides and breast cancer, and for BMI and triglycerides in relation to liver cancer among men (n cases = 444). These findings are unlikely to be due to chance owing to the replication. The linear age-interactions in breast cancer may suggest an influence by other age-related factors than menopause; however, further investigation of age-related effect modifiers in both breast and liver cancer is needed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- age interaction
- cancer risk
- cohort study
- metabolic factors
- survival analysis
- age interaction
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Häggström, Chris ...
-
Jonsson, Håkan
-
Bjørge, Tone
-
Nagel, Gabriele
-
Manjer, Jonas
-
Ulmer, Hanno
-
visa fler...
-
Drake, Isabel
-
Ghaderi, Sara
-
Lang, Alois
-
Engeland, Anders
-
Stattin, Pär
-
Stocks, Tanja
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Folkhälsovetensk ...
- Artiklar i publikationen
-
International Jo ...
- Av lärosätet
-
Lunds universitet
-
Umeå universitet
-
Uppsala universitet