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Epithelial–mesenchy...
Epithelial–mesenchymal transition, a spectrum of states : Role in lung development, homeostasis, and disease
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- Jolly, Mohit Kumar (författare)
- Rice University
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- Ward, Chris (författare)
- University of Newcastle upon Tyne
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- Eapen, Mathew Suji (författare)
- University of Tasmania
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- Myers, Stephen (författare)
- University of Tasmania
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- Hallgren, Oskar (författare)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Department of Experimental Medical Science,Faculty of Medicine,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund
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- Levine, Herbert (författare)
- Rice University
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- Sohal, Sukhwinder Singh (författare)
- University of Tasmania
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(creator_code:org_t)
- 2017-07-21
- 2018
- Engelska.
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Ingår i: Developmental Dynamics. - : Wiley. - 1058-8388. ; 247:3, s. 346-358
- Relaterad länk:
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http://dx.doi.org/10...
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https://anatomypubs....
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Epithelial–mesenchymal transition (EMT) plays key roles during lung development and many lung diseases such as chronic obstructive pulmonary disease (COPD), lung cancer, and pulmonary fibrosis. Here, integrating morphological observations with underlying molecular mechanisms, we highlight the functional role of EMT in lung development and injury repair, and discuss how it can contribute to pathogenesis of chronic lung disease. We discuss the evidence of manifestation of EMT and its potential driving role in COPD, idiopathic pulmonary fibrosis (IPF), bronchiolitis obliterans syndrome (BOS), and lung cancer, while noting that all cells need not display a full EMT in any of these contexts, i.e., often cells co-express epithelial and mesenchymal markers but do not fully convert to extracellular matrix (ECM) -producing fibroblasts. Finally, we discuss recent therapeutic attempts to restrict EMT in chronic lung disease. Developmental Dynamics 247:346–358, 2018.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- chronic pulmonary obstructive disease (COPD)
- epithelial–mesenchymal transition (EMT)
- hybrid epithelial/mesenchymal
- idiopathic pulmonary fibrosis (IPF)
- lung cancer
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- for (ämneskategori)
- ref (ämneskategori)
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