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Innovative three-di...
Innovative three-dimensional models for understanding mechanisms underlying lung diseases : powerful tools for translational research
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- Nizamoglu, Mehmet (författare)
- University Medical Center Groningen
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- Joglekar, Mugdha M. (författare)
- University Medical Center Groningen
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- Almeida, Catarina R. (författare)
- University of Aveiro
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- Callerfelt, Anna Karin Larsson (författare)
- Lund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,LTH profilområde: Aerosoler,LTH profilområden,Lunds Tekniska Högskola,Lung Biology,Lund University Research Groups,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH
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- Dupin, Isabelle (författare)
- University of Bordeaux
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- Guenat, Olivier T. (författare)
- Bern University Hospital
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- Henrot, Pauline (författare)
- Centre Hospitalier Universitaire de Bordeaux
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van Os, Lisette (författare)
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- Otero, Jorge (författare)
- University of Barcelona,CIBER Enfermedades Respiratorias (CIBERES)
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- Elowsson, Linda (författare)
- Lund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,Lung Biology,Lund University Research Groups
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- Farre, Ramon (författare)
- University of Barcelona,Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),CIBER Enfermedades Respiratorias (CIBERES)
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- Burgess, Janette K. (författare)
- University Medical Center Groningen
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: European Respiratory Review. - 0905-9180. ; 32:169
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Chronic lung diseases result from alteration and/or destruction of lung tissue, inevitably causing decreased breathing capacity and quality of life for patients. While animal models have paved the way for our understanding of pathobiology and the development of therapeutic strategies for disease management, their translational capacity is limited. There is, therefore, a well-recognised need for innovative in vitro models to reflect chronic lung diseases, which will facilitate mechanism investigation and the advancement of new treatment strategies. In the last decades, lungs have been modelled in healthy and diseased conditions using precision-cut lung slices, organoids, extracellular matrix-derived hydrogels and lung-on-chip systems. These three-dimensional models together provide a wide spectrum of applicability and mimicry of the lung microenvironment. While each system has its own limitations, their advantages over traditional two-dimensional culture systems, or even over animal models, increases the value of in vitro models. Generating new and advanced models with increased translational capacity will not only benefit our understanding of the pathobiology of lung diseases but should also shorten the timelines required for discovery and generation of new therapeutics. This article summarises and provides an outline of the European Respiratory Society research seminar “Innovative 3D models for understanding mechanisms underlying lung diseases: powerful tools for translational research”, held in Lisbon, Portugal, in April 2022. Current in vitro models developed for recapitulating healthy and diseased lungs are outlined and discussed with respect to the challenges associated with them, efforts to develop best practices for model generation, characterisation and utilisation of models and state-of-the-art translational potential.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
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Nizamoglu, Mehme ...
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Joglekar, Mugdha ...
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Almeida, Catarin ...
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Callerfelt, Anna ...
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Dupin, Isabelle
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Guenat, Olivier ...
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visa fler...
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Henrot, Pauline
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van Os, Lisette
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Otero, Jorge
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Elowsson, Linda
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Farre, Ramon
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Burgess, Janette ...
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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och Lungmedicin och ...
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Lunds universitet