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Sökning: onr:"swepub:oai:lup.lub.lu.se:27f8d4e3-f421-4b06-a0f4-ac2b1f3f7f3d" > Bivariate genome-wi...

  • Haljas, KadriUniversity of Helsinki (författare)

Bivariate genome-wide association study of depressive symptoms with type 2 diabetes and quantitative glycemic traits

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2018
  • 10 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:27f8d4e3-f421-4b06-a0f4-ac2b1f3f7f3d
  • https://lup.lub.lu.se/record/27f8d4e3-f421-4b06-a0f4-ac2b1f3f7f3dURI
  • https://doi.org/10.1097/PSY.0000000000000555DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Objective: Shared genetic background may explain phenotypic associations between depression and Type 2 diabetes (T2D). We aimed to study, on a genome-wide level, if genetic correlation and pleiotropic loci exist between depressive symptoms and T2D or glycemic traits. Methods: We estimated single-nucleotide polymorphism (SNP)-based heritability and analyzed genetic correlation between depressive symptoms and T2D and glycemic traits with the linkage disequilibrium score regression by combining summary statistics of previously conducted meta-analyses for depressive symptoms by CHARGE consortium (N = 51,258), T2D by DIAGRAM consortium (N = 34,840 patients and 114,981 controls), fasting glucose, fasting insulin, and homeostatic model assessment of β-cell function and insulin resistance by MAGIC consortium (N = 58,074). Finally, we investigated pleiotropic loci using a bivariate genome-wide association study approach with summary statistics from genome-wide association study meta-analyses and reported loci with genome-wide significant bivariate association p value (p < 5 10−8). Biological annotation and function of significant pleiotropic SNPs were assessed in several databases. Results: The SNP-based heritability ranged from 0.04 to 0.10 in each individual trait. In the linkage disequilibrium score regression analyses, depressive symptoms showed no significant genetic correlation with T2D or glycemic traits (p > 0.37). However, we identified pleiotropic genetic variations for depressive symptoms and T2D (in the IGF2BP2, CDKAL1, CDKN2B-AS, and PLEKHA1 genes), and fasting glucose (in the MADD, CDKN2B-AS, PEX16, and MTNR1B genes). Conclusions: We found no significant overall genetic correlations between depressive symptoms, T2D, or glycemic traits suggesting major differences in underlying biology of these traits. However, several potential pleiotropic loci were identified between depressive symptoms, T2D, and fasting glucose, suggesting that previously established phenotypic associations may be partly explained by genetic variation in these specific loci.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Amare, Azmeraw T.University Medical Center Groningen,University of Groningen (författare)
  • Alizadeh, Behrooz Z.University Medical Center Groningen,University of Groningen (författare)
  • Hsu, Yi HsiangHarvard University (författare)
  • Mosley, ThomasUniversity of Mississippi Medical Center,University of Mississippi (författare)
  • Newman, AnneUniversity of Pittsburgh (författare)
  • Murabito, JoanneNational Heart Lung and Blood Institute,Boston University (författare)
  • Tiemeier, HenningErasmus University Rotterdam,Erasmus University Medical Center (författare)
  • Tanaka, ToshikoNational Institute on Aging, United States (författare)
  • Van Duijn, CorneliaErasmus University Rotterdam,Centre for Medical Systems Biology, Leiden,Erasmus University Medical Center (författare)
  • Ding, JingzhongWake Forest University (författare)
  • Llewellyn, David J.University of Exeter (författare)
  • Bennett, David A.Rush Alzheimer's Disease Center (författare)
  • Terracciano, AntonioFlorida State University (författare)
  • Launer, LenoreNational Institute on Aging, United States (författare)
  • Ladwig, Karl HeinzKlinikum rechts der Isar,German Center for Diabetes Research,Helmholtz Zentrum München (författare)
  • Cornelis, Marylin C.Northwestern University (författare)
  • Teumer, AlexanderUniversity of Greifswald (författare)
  • Grabe, HansHelios Hanseklinikum Stralsund,German Center for Neurodegenerative Diseases (DZNE), Bonn (författare)
  • Kardia, Sharon L.R.University of Michigan (författare)
  • Ware, Erin B.University of Michigan (författare)
  • Smith, Jennifer A.University of Michigan (författare)
  • Snieder, HaroldUniversity Medical Center Groningen,University of Groningen (författare)
  • Eriksson, Johan G.University of Helsinki,Folkhälsan Research Center (författare)
  • Groop, LeifLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Institute for Molecular Medicine Finland (FIMM)(Swepub:lu)endo-lgr (författare)
  • Räikkönen, KatriUniversity of Helsinki (författare)
  • Lahti, JariUniversity of Helsinki (författare)
  • University of HelsinkiUniversity Medical Center Groningen (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Psychosomatic Medicine80:3, s. 242-2510033-3174

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