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How Communicating P...
How Communicating Polygenic and Clinical Risk for Atherosclerotic Cardiovascular Disease Impacts Health Behavior : an Observational Follow-up Study
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- Widén, Elisabeth (författare)
- University of Helsinki
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- Junna, Nella (författare)
- University of Helsinki
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- Ruotsalainen, Sanni (författare)
- University of Helsinki
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- Surakka, Ida (författare)
- University of Helsinki
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- Mars, Nina (författare)
- University of Michigan Medical School,University of Helsinki
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- Ripatti, Pietari (författare)
- University of Helsinki,Helsinki University Central Hospital
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- Partanen, Juulia J. (författare)
- Folkhälsan Research Center,University of Helsinki
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- Aro, Johanna (författare)
- University of Helsinki
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- Mustonen, Pekka (författare)
- Duodecim Publishing Company Ltd
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- Tuomi, Tiinamaija (författare)
- Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups,University of Helsinki
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- Palotie, Aarno (författare)
- Massachusetts General Hospital,University of Helsinki
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- Salomaa, Veikko (författare)
- Finnish National Institute for Health and Welfare
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- Kaprio, Jaakko (författare)
- University of Helsinki
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- Partanen, Jukka (författare)
- Finnish Red Cross Blood Transfusion Service
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- Hotakainen, Kristina (författare)
- Mehiläinen Oy
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- Pöllänen, Pasi (författare)
- University of Helsinki
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- Ripatti, Samuli (författare)
- University of Helsinki
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(creator_code:org_t)
- 2022
- 2022
- Engelska.
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Ingår i: Circulation: Genomic and Precision Medicine. - 2574-8300. ; 15:2, s. 003459-003459
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Prediction tools that combine polygenic risk scores with clinical factors provide a new opportunity for improved prediction and prevention of atherosclerotic cardiovascular disease, but the clinical utility of polygenic risk score has remained unclear. Methods: We collected a prospective cohort of 7342 individuals (64% women, mean age 56 years) and estimated their 10-year risk for atherosclerotic cardiovascular disease both by a traditional risk score and a composite score combining the effect of a polygenic risk score and clinical risk factors. We then tested how returning the personal risk information with an interactive web-tool impacted on the participants' health behavior. Results: When reassessed after 1.5 years by a clinical visit and questionnaires, 20.8% of individuals at high (>10%) 10-year atherosclerotic cardiovascular disease risk had seen a doctor, 12.4% reported weight loss, 14.2% of smokers had quit smoking, and 15.4% had signed up for health coaching online. Altogether, 42.6% of persons at high risk had made one or more health behavioral changes versus 33.5% of persons at low/average risk such that higher baseline risk predicted a favorable change (OR [CI], 1.53 [1.37-1.72] for persons at high risk versus the rest, P<0.001), with both high clinical (P<0.001) and genomic risk (OR [CI], 1.10 [1.03-1.17], P=0.003) contributing independently. Conclusions: Web-based communication of personal atherosclerotic cardiovascular disease risk-data including polygenic risk to middle-aged persons motivates positive changes in health behavior and the propensity to seek care. It supports integration of genomic information into clinical risk calculators as a feasible approach to enhance disease prevention.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- cardiovascular disease
- communication
- genomics
- risk factor
- weight loss
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Widén, Elisabeth
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Junna, Nella
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Ruotsalainen, Sa ...
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Surakka, Ida
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Mars, Nina
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Ripatti, Pietari
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visa fler...
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Partanen, Juulia ...
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Aro, Johanna
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Mustonen, Pekka
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Tuomi, Tiinamaij ...
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Palotie, Aarno
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Salomaa, Veikko
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Kaprio, Jaakko
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Partanen, Jukka
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Hotakainen, Kris ...
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Pöllänen, Pasi
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Ripatti, Samuli
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Circulation: Gen ...
- Av lärosätet
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Lunds universitet