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Core Lab Adjudicati...
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Elkoumy, AhmedGalway University Hospital
(författare)
Core Lab Adjudication of the ACURATE neo2 Hemodynamic Performance Using Computed-Tomography-Corrected Left Ventricular Outflow Tract Area
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:287b58fb-4e9f-4d28-923f-35a1b83fbb43
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https://lup.lub.lu.se/record/287b58fb-4e9f-4d28-923f-35a1b83fbb43URI
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https://doi.org/10.3390/jcm11206103DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:151067964URI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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(1) Background: Hemodynamic assessment of prosthetic heart valves using conventional 2D transthoracic Echocardiography-Doppler (2D-TTE) has limitations. Of those, left ventricular outflow tract (LVOT) area measurement is one of the major limitations of the continuity equation, which assumes a circular LVOT. (2) Methods: This study comprised 258 patients with severe aortic stenosis (AS), who were treated with the ACURATE neo2. The LVOT area and its dependent Doppler-derived parameters, including effective orifice area (EOA) and stroke volume (SV), in addition to their indexed values, were calculated from post-TAVI 2D-TTE. In addition, the 3D-LVOT area from pre-procedural MDCT scans was obtained and used to calculate corrected Doppler-derived parameters. The incidence rates of prosthesis patient mismatch (PPM) were compared between the 2D-TTE and MDCT-based methods (3) Results: The main results show that the 2D-TTE measured LVOT is significantly smaller than 3D-MDCT (350.4 ± 62.04 mm2 vs. 405.22 ± 81.32 mm2) (95% Credible interval (CrI) of differences: −55.15, −36.09), which resulted in smaller EOA (2.25 ± 0.59 vs. 2.58 ± 0.63 cm2) (Beta = −0.642 (95%CrI of differences: −0.85, −0.43), and lower SV (73.88 ± 21.41 vs. 84.47 ± 22.66 mL), (Beta = −7.29 (95% CrI: −14.45, −0.14)), respectively. PPM incidence appears more frequent with 2D-TTE- than 3D-MDCT-corrected measurements (based on the EOAi) 8.52% vs. 2.32%, respectively. In addition, significant differences regarding the EOA among the three valve sizes (S, M and L) were seen only with the MDCT, but not on 2D-TTE. (4) Conclusions: The corrected continuity equation by combining the 3D-LVOT area from MDCT with the TTE Doppler parameters might provide a more accurate assessment of hemodynamic parameters and PPM diagnosis in patients treated with TAVI. The ACURATE neo2 THV has a large EOA and low incidence of PPM using the 3D-corrected LVOT area than on 2D-TTE. These findings need further confirmation on long-term follow-up and in other studies.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Rück, AndreasKarolinska Institutet,Karolinska University Hospital
(författare)
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Kim, Won KeunMax Planck Institute for Heart and Lung Research
(författare)
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Abdel-Wahab, MohamedLeipzig University
(författare)
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Abdelshafy, MahmoudGalway University Hospital
(författare)
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De Backer, OleCopenhagen University Hospital
(författare)
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Elzomor, HeshamGalway University Hospital
(författare)
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Hengstenberg, ChristianMedical University of Vienna
(författare)
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Mohamed, Sameh K.Galway University Hospital
(författare)
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Saleh, NawzadKarolinska Institutet,Karolinska University Hospital
(författare)
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Arsang-Jang, ShahramGalway University Hospital
(författare)
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Bjursten, HenrikLund University,Lunds universitet,Skonsammare hjärtkirurgi,Forskargrupper vid Lunds universitet,Less invasive cardiac surgery,Lund University Research Groups,Skåne University Hospital(Swepub:lu)thor-hjo
(författare)
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Simpkin, AndrewNational University of Ireland Galway
(författare)
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Meduri, Christopher U.Karolinska University Hospital
(författare)
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Soliman, OsamaGalway University Hospital
(författare)
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Karolinska InstitutetGalway University Hospital
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Clinical Medicine: MDPI AG11:20, s. 1-122077-0383
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Till lärosätets databas
- Av författaren/redakt...
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Elkoumy, Ahmed
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Rück, Andreas
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Kim, Won Keun
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Abdel-Wahab, Moh ...
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Abdelshafy, Mahm ...
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De Backer, Ole
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visa fler...
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Elzomor, Hesham
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Hengstenberg, Ch ...
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Mohamed, Sameh K ...
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Saleh, Nawzad
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Arsang-Jang, Sha ...
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Bjursten, Henrik
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Simpkin, Andrew
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Meduri, Christop ...
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Soliman, Osama
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Radiologi och bi ...
- Artiklar i publikationen
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Journal of Clini ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet