Levels of DNA damage (Micronuclei) in patients suffering from chronic kidney disease. Role of GST polymorphisms

Pastor, SusanaCIBER Epidemiology and Public Health (CIBERESP),Autonomous University of Barcelona (författare)

Chronic kidney disease (CKD) patients are characterized by the presence of high levels of DNA damage, and a poor response to ionizing radiation. In this study, we proposed that variants in GST genes could explain this fact. One-hundred twenty seven CKD patients and one-hundred forty five controls constituted the studied groups. Micronuclei (MN) frequency was determined in peripheral blood lymphocytes at both basal level, and after challenging the cells with 0.5 Gy of ionizing radiation. The following polymorphisms: GSTP1 (rs749174), GSTO1 (rs2164624), and GSTO2 (rs156697) were evaluated in the two groups. Results indicate that gene variants were distributed differentially between CKD patients and controls. Although GSTO1 and GSTO2 variants were associated with lower levels of MN, this was observed in both CKD patients and controls. When net MN values were determined after irradiation, GSTO1 and GSTO2 variants were also associated with lower MN-frequencies. On the contrary, individuals with the GSTP1 variant showed higher values of induced MN. In conclusion, we have demonstrate that the selected GST polymorphism play a role in the incidence of CKD, and affects the levels of MN. Interestingly, the modulating effects observed on both, the basal and induced levels of DNA damage, are characteristic of the overall population, not only of the CKD patients.

Rodríguez-Ribera, LaraAutonomous University of Barcelona (författare)
Corredor, ZurayAutonomous University of Barcelona (författare)
da Silva Filho, Miguel InácioGerman Cancer Research Centre(Swepub:lu)med-md_ (författare)
Hemminki, KariLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Center for Primary Health Care Research,German Cancer Research Centre(Swepub:lu)med-khk (författare)
Coll, ElisabethFundació Puigvert (författare)
Försti, AstaLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre,Center for Primary Health Care Research(Swepub:lu)med-asf (författare)
Marcos, RicardAutonomous University of Barcelona,CIBER Epidemiology and Public Health (CIBERESP) (författare)
CIBER Epidemiology and Public Health (CIBERESP)Autonomous University of Barcelona (creator_code:org_t)

Ingår i:Mutation Research - Genetic Toxicology and Environmental Mutagenesis: Elsevier BV836, s. 41-461383-5718

Av författaren/redakt...: Pastor, Susana; Rodríguez-Ribera ...; Corredor, Zuray; da Silva Filho, ...; Hemminki, Kari; Coll, Elisabeth; visa fler...; Försti, Asta; Marcos, Ricard; visa färre...

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