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Clonal Hematopoiesi...
Clonal Hematopoiesis and Risk of Incident Lung Cancer
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- Tian, Ruiyi (författare)
- Washington University in St. Louis
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- Wiley, Brian (författare)
- Washington University in St. Louis
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- Liu, Jie (författare)
- Washington University in St. Louis
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- Zong, Xiaoyu (författare)
- Washington University in St. Louis
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- Truong, Buu (författare)
- Massachusetts General Hospital,Massachusetts Institute of Technology
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- Zhao, Stephanie (författare)
- Washington University in St. Louis
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- Uddin, Md Mesbah (författare)
- Massachusetts General Hospital,Massachusetts Institute of Technology
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- Niroula, Abhishek (författare)
- Lund University,Lunds universitet,Hematogenomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Massachusetts Institute of Technology,Dana-Farber Cancer Institute
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- Miller, Christopher A. (författare)
- Washington University in St. Louis
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- Mukherjee, Semanti (författare)
- Weill Cornell Medical College,Memorial Sloan-Kettering Cancer Center
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- Heiden, Brendan T. (författare)
- Washington University in St. Louis
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- Luo, Jingqin (författare)
- Washington University in St. Louis
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- Puri, Varun (författare)
- Washington University in St. Louis
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- Kozower, Benjamin D. (författare)
- Washington University in St. Louis
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- Walter, Matthew J. (författare)
- Washington University in St. Louis
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- Ding, Li (författare)
- Washington University in St. Louis
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- Link, Daniel C. (författare)
- Washington University in St. Louis
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- Amos, Christopher I. (författare)
- Baylor College of Medicine
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- Ebert, Benjamin L. (författare)
- Dana-Farber Cancer Institute,Massachusetts Institute of Technology,Howard Hughes Medical Institute
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- Govindan, Ramaswamy (författare)
- Washington University in St. Louis
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- Natarajan, Pradeep (författare)
- Massachusetts General Hospital,Massachusetts Institute of Technology,Harvard Medical School
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- Bolton, Kelly L. (författare)
- Washington University in St. Louis
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- Cao, Yin (författare)
- Washington University in St. Louis
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Washington University in St Louis Massachusetts General Hospital (creator_code:org_t)
- 2023
- 2023
- Engelska 11 s.
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Ingår i: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. - 0732-183X. ; 41:7, s. 1423-1433
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- PURPOSE: To prospectively examine the association between clonal hematopoiesis (CH) and subsequent risk of lung cancer. METHODS: Among 200,629 UK Biobank (UKBB) participants with whole-exome sequencing, CH was identified in a nested case-control study of 832 incident lung cancer cases and 3,951 controls (2006-2019) matched on age and year at blood draw, sex, race, and smoking status. A similar nested case-control study (141 cases/652 controls) was conducted among 27,975 participants with whole-exome sequencing in the Mass General Brigham Biobank (MGBB, 2010-2021). In parallel, we compared CH frequency in published data from 5,003 patients with solid tumor (2,279 lung cancer) who had pretreatment blood sequencing performed through Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets. RESULTS: In UKBB, the presence of CH was associated with increased risk of lung cancer (cases: 12.5% v controls: 8.7%; multivariable-adjusted odds ratio [OR], 1.36; 95% CI, 1.06 to 1.74). The association remained robust after excluding participants with chronic obstructive pulmonary disease. No significant interactions with known risk factors, including polygenic risk score and C-reactive protein, were identified. In MGBB, we observed similar enrichment of CH in lung cancer (cases: 15.6% v controls: 12.7%). The meta-analyzed OR (95% CI) of UKBB and MGBB was 1.35 (1.08 to 1.68) for CH overall and 1.61 (1.19 to 2.18) for variant allele frequencies ≥ 10%. In Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets, CH with a variant allele frequency ≥ 10% was enriched in pretreatment lung cancer compared with other tumors after adjusting for age, sex, and smoking (OR for lung v breast cancer: 1.61; 95% CI, 1.03 to 2.53). CONCLUSION: Independent of known risk factors, CH is associated with increased risk of lung cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Tian, Ruiyi
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Wiley, Brian
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Liu, Jie
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Zong, Xiaoyu
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Truong, Buu
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Zhao, Stephanie
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visa fler...
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Uddin, Md Mesbah
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Niroula, Abhishe ...
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Miller, Christop ...
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Mukherjee, Seman ...
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Heiden, Brendan ...
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Luo, Jingqin
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Puri, Varun
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Kozower, Benjami ...
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Walter, Matthew ...
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Ding, Li
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Link, Daniel C.
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Amos, Christophe ...
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Ebert, Benjamin ...
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Govindan, Ramasw ...
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Natarajan, Prade ...
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Bolton, Kelly L.
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Cao, Yin
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- MEDICIN OCH HÄLSOVETENSKAP
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Journal of clini ...
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