Sökning: onr:"swepub:oai:lup.lub.lu.se:2a6cada5-4721-413b-a436-b6e078744128" > Circulating copper ...
Fältnamn | Indikatorer | Metadata |
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000 | 06956naa a2201057 4500 | |
001 | oai:lup.lub.lu.se:2a6cada5-4721-413b-a436-b6e078744128 | |
003 | SwePub | |
008 | 181002s2017 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-133525 | |
009 | oai:prod.swepub.kib.ki.se:135302690 | |
024 | 7 | a https://lup.lub.lu.se/record/2a6cada5-4721-413b-a436-b6e0787441282 URI |
024 | 7 | a https://doi.org/10.1038/bjc.2017.12 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1335252 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1353026902 URI |
040 | a (SwePub)lud (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Stepien, Magdalenau International Agency for Research on Cancer, World Health Organization4 aut |
245 | 1 0 | a Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans |
264 | c 2017-02-02 | |
264 | 1 | b Springer Science and Business Media LLC,c 2017 |
300 | a 9 s. | |
520 | a BACKGROUND: Copper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and their ratio (Cu/Zn) in relation to hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBD) and gall bladder and biliary tract (GBTC) cancers.METHODS: A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. Serum zinc and copper levels were measured in baseline blood samples by total reflection X-ray fluorescence in cancer cases (HCC n=106, IHDB n=34, GBTC n=96) and their matched controls (1:1). The Cu/Zn ratio, an indicator of the balance between the micronutrients, was computed. Multivariable adjusted odds ratios and 95% confidence intervals (OR; 95% CI) were used to estimate cancer risk.RESULTS: For HCC, the highest vs lowest tertile showed a strong inverse association for zinc (OR=0.36; 95% CI: 0.13-0.98, Ptrend=0.0123), but no association for copper (OR=1.06; 95% CI: 0.45-2.46, Ptrend=0.8878) in multivariable models. The calculated Cu/Zn ratio showed a positive association for HCC (OR=4.63; 95% CI: 1.41-15.27, Ptrend=0.0135). For IHBC and GBTC, no significant associations were observed.CONCLUSIONS: Zinc may have a role in preventing liver-cancer development, but this finding requires further investigation in other settings. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
653 | a Aged | |
653 | a Biliary Tract Neoplasms/epidemiology | |
653 | a Carcinoma, Hepatocellular/epidemiology | |
653 | a Case-Control Studies | |
653 | a Copper/blood | |
653 | a Europe/epidemiology | |
653 | a Female | |
653 | a Humans | |
653 | a Liver Neoplasms/epidemiology | |
653 | a Male | |
653 | a Middle Aged | |
653 | a Prospective Studies | |
653 | a Zinc/blood | |
653 | a copper | |
700 | 1 | a Hughes, David Ju Royal College of Surgeons in Ireland4 aut |
700 | 1 | a Hybsier, Sandrau Charité - University Medicine Berlin4 aut |
700 | 1 | a Bamia, Christinau Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens4 aut |
700 | 1 | a Tjønneland, Anneu Danish Cancer Society4 aut |
700 | 1 | a Overvad, Kimu Aarhus University4 aut |
700 | 1 | a Affret, Aurélieu Institut Gustave Roussy,University of Paris-Saclay4 aut |
700 | 1 | a His, Mathildeu University of Paris-Saclay,Institut Gustave Roussy4 aut |
700 | 1 | a Boutron-Ruault, Marie-Christineu Institut Gustave Roussy,University of Paris-Saclay4 aut |
700 | 1 | a Katzke, Verenau German Cancer Research Centre4 aut |
700 | 1 | a Kühn, Tilmanu German Cancer Research Centre4 aut |
700 | 1 | a Aleksandrova, Krasimira4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Lagiou, Pagona4 aut |
700 | 1 | a Orfanos, Phlippos4 aut |
700 | 1 | a Palli, Domenico4 aut |
700 | 1 | a Sieri, Sabina4 aut |
700 | 1 | a Tumino, Rosario4 aut |
700 | 1 | a Ricceri, Fulvio4 aut |
700 | 1 | a Panico, Salvatore4 aut |
700 | 1 | a Bueno-de-Mesquita, H B As4 aut |
700 | 1 | a Peeters, Petra H4 aut |
700 | 1 | a Weiderpass, Elisabeteu Karolinska Institutet4 aut |
700 | 1 | a Lasheras, Cristina4 aut |
700 | 1 | a Bonet Bonet, Catalina4 aut |
700 | 1 | a Molina-Portillo, Elena4 aut |
700 | 1 | a Dorronsoro, Miren4 aut |
700 | 1 | a Huerta, José María4 aut |
700 | 1 | a Barricarte, Aurelio4 aut |
700 | 1 | a Ohlsson, Bodilu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)kir-boh |
700 | 1 | a Sjöberg, Klasu Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)medf-ksj |
700 | 1 | a Werner, Mårtenu Umeå universitet,Umeå University,Medicin4 aut0 (Swepub:umu)manwer04 |
700 | 1 | a Shungin, Dmitryu Umeå universitet,Umeå University,Institutionen för odontologi,Medicin4 aut0 (Swepub:lu)med-dsn |
700 | 1 | a Wareham, Nick4 aut |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Travis, Ruth C4 aut |
700 | 1 | a Freisling, Heinz4 aut |
700 | 1 | a Cross, Amanda Ju International Agency for Research on Cancer, World Health Organization4 aut |
700 | 1 | a Schomburg, Lutz4 aut |
700 | 1 | a Jenab, Mazdau International Agency for Research on Cancer, World Health Organization4 aut |
710 | 2 | a International Agency for Research on Cancer, World Health Organizationb Royal College of Surgeons in Ireland4 org |
773 | 0 | t British Journal of Cancerd : Springer Science and Business Media LLCg 116:5, s. 688-696q 116:5<688-696x 1532-1827x 0007-0920 |
856 | 4 | u http://dx.doi.org/10.1038/bjc.2017.1x freey FULLTEXT |
856 | 4 | u https://www.nature.com/articles/bjc20171.pdf |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1095612/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://lup.lub.lu.se/record/2a6cada5-4721-413b-a436-b6e078744128 |
856 | 4 8 | u https://doi.org/10.1038/bjc.2017.1 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133525 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:135302690 |
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