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Limited immune surv...
Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease
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- Buggert, Marcus (författare)
- Karolinska Institutet,University of Pennsylvania,Karolinska University Hospital
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- Nguyen, Son (författare)
- University of Pennsylvania
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- McLane, Laura M. (författare)
- University of Pennsylvania
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- Steblyanko, Maria (författare)
- Thomas Jefferson University
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- Anikeeva, Nadia (författare)
- Thomas Jefferson University
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- Paquin-Proulx, Dominic (författare)
- Henry M. Jackson Foundation for the Advancement of Military Medicine,Walter Reed Army Institute of Research,Karolinska University Hospital
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- Del Rio Estrada, Perla M. (författare)
- Instituto Nacional de Enfermedades Respiratorias
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- Ablanedo-Terrazas, Yuria (författare)
- Instituto Nacional de Enfermedades Respiratorias
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- Noyan, Kajsa (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Reuter, Morgan A. (författare)
- University of Pennsylvania
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- Demers, Korey (författare)
- University of Pennsylvania
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- Sandberg, Johan K. (författare)
- Karolinska Institutet
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- Eller, Michael A. (författare)
- Henry M. Jackson Foundation for the Advancement of Military Medicine,Walter Reed Army Institute of Research
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- Streeck, Hendrik (författare)
- University Hospital Essen,Walter Reed Army Institute of Research,Henry M. Jackson Foundation for the Advancement of Military Medicine
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- Jansson, Marianne (författare)
- Karolinska Institute,Lund University,Lunds universitet,Institutionen för laboratoriemedicin,Medicinska fakulteten,Department of Laboratory Medicine,Faculty of Medicine
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- Nowak, Piotr (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Sönnerborg, Anders (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Canaday, David H. (författare)
- Louis Stokes Cleveland VA Medical Center,Case Western Reserve University
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- Naji, Ali (författare)
- University of Pennsylvania
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- Wherry, E. John (författare)
- University of Pennsylvania
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- Robb, Merlin L. (författare)
- Walter Reed Army Institute of Research,Henry M. Jackson Foundation for the Advancement of Military Medicine
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- Deeks, Steven G. (författare)
- University of California, San Francisco
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- Reyes-Teran, Gustavo (författare)
- Instituto Nacional de Enfermedades Respiratorias
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- Sykulev, Yuri (författare)
- Thomas Jefferson University
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- Karlsson, Annika C. (författare)
- Karolinska Institutet,Karolinska Institute
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- Betts, Michael R. (författare)
- University of Pennsylvania
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(creator_code:org_t)
- 2018-04-13
- 2018
- Engelska.
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Ingår i: PLoS Pathogens. - : Public Library of Science (PLoS). - 1553-7374. ; 14:4
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://journals.plo...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- CD4+ T cells subsets have a wide range of important helper and regulatory functions in the immune system. Several studies have specifically suggested that circulating effector CD4+ T cells may play a direct role in control of HIV replication through cytolytic activity or autocrine β-chemokine production. However, it remains unclear whether effector CD4+ T cells expressing cytolytic molecules and β-chemokines are present within lymph nodes (LNs), a major site of HIV replication. Here, we report that expression of β-chemokines and cytolytic molecules are enriched within a CD4+ T cell population with high levels of the T-box transcription factors T-bet and eomesodermin (Eomes). This effector population is predominately found in peripheral blood and is limited in LNs regardless of HIV infection or treatment status. As a result, CD4+ T cells generally lack effector functions in LNs, including cytolytic capacity and IFNγ and β-chemokine expression, even in HIV elite controllers and during acute/early HIV infection. While we do find the presence of degranulating CD4+ T cells in LNs, these cells do not bear functional or transcriptional effector T cell properties and are inherently poor to form stable immunological synapses compared to their peripheral blood counterparts. We demonstrate that CD4+ T cell cytolytic function, phenotype, and programming in the peripheral blood is dissociated from those characteristics found in lymphoid tissues. Together, these data challenge our current models based on blood and suggest spatially and temporally dissociated mechanisms of viral control in lymphoid tissues.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Buggert, Marcus
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Nguyen, Son
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McLane, Laura M.
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Steblyanko, Mari ...
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Anikeeva, Nadia
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Paquin-Proulx, D ...
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visa fler...
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Del Rio Estrada, ...
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Ablanedo-Terraza ...
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Noyan, Kajsa
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Reuter, Morgan A ...
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Demers, Korey
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Sandberg, Johan ...
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Eller, Michael A ...
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Streeck, Hendrik
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Jansson, Mariann ...
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Nowak, Piotr
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Sönnerborg, Ande ...
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Canaday, David H ...
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Naji, Ali
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Wherry, E. John
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Robb, Merlin L.
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Deeks, Steven G.
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Reyes-Teran, Gus ...
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Sykulev, Yuri
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Karlsson, Annika ...
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Betts, Michael R ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Immunologi inom ...
- Artiklar i publikationen
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PLoS Pathogens
- Av lärosätet
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Lunds universitet
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Karolinska Institutet