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A longitudinal stud...
A longitudinal study of plasma BAFF levels in mothers and their infants in Uganda, and correlations with subsets of B cells
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- Rönnberg, Caroline (författare)
- Karolinska Institute
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- Lugaajju, Allan (författare)
- Karolinska Institute,Makerere University
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- Nyman, Anna (författare)
- Skåne University Hospital
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- Hammar, Ulf (författare)
- Karolinska Institute
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- Bottai, Matteo (författare)
- Karolinska Institutet,Karolinska Institute
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- Lautenbach, Maximilian Julius (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Sundling, Christopher (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Kironde, Fred (författare)
- Makerere University
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- Persson, Kristina E.M. (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Malaria och Babesia,Forskargrupper vid Lunds universitet,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Malaria and Babesia,Lund University Research Groups
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(creator_code:org_t)
- 2021-01-19
- 2021
- Engelska.
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 16:1 January
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http://dx.doi.org/10... (free)
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Abstract
Ämnesord
Stäng
- Malaria is a potentially life-threatening disease with approximately half of the world’s population at risk. Young children and pregnant women are hit hardest by the disease. B cells and antibodies are part of an adaptive immune response protecting individuals continuously exposed to the parasite. An infection with Plasmodium falciparum can cause dysregulation of B cell homeostasis, while antibodies are known to be key in controlling symptoms and parasitemia. BAFF is an instrumental cytokine for the development and maintenance of B cells. Pregnancy alters the immune status and renders previously clinically immune women at risk of severe malaria, potentially due to altered B cell responses associated with changes in BAFF levels. In this prospective study, we investigated the levels of BAFF in a malaria-endemic area in mothers and their infants from birth up to 9 months. We found that BAFF-levels are significantly higher in infants than in mothers. BAFF is highest in cord blood and then drops rapidly, but remains significantly higher in infants compared to mothers even at 9 months of age. We further correlated BAFF levels to P. falciparum-specific antibody levels and B cell frequencies and found a negative correlation between BAFF and both P. falciparum-specific and total proportions of IgG+ memory B cells, as well as CD27− memory B cells, indicating that exposure to both malaria and other diseases affect the development of B-cell memory and that BAFF plays a part in this. In conclusion, we have provided new information on how natural immunity against malaria is formed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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