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Longitudinal monoam...
Longitudinal monoaminergic PET imaging of chronic proteasome inhibition in minipigs
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- Lillethorup, Thea P. (författare)
- Aarhus University Hospital,Aarhus University
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- Glud, Andreas N. (författare)
- Aarhus University
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- Alstrup, Aage K.O. (författare)
- Aarhus University,Aarhus University Hospital
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visa fler...
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- Noer, Ove (författare)
- Aarhus University Hospital,Aarhus University
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- Nielsen, Erik H.T. (författare)
- Aarhus University,Aarhus University Hospital
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- Schacht, Anna C. (författare)
- Aarhus University Hospital,Aarhus University
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- Landeck, Natalie (författare)
- Lund University,Lunds universitet,Brain Repair and Imaging in Neural Systems (BRAINS),Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Kirik, Deniz (författare)
- Lund University,Lunds universitet,Brain Repair and Imaging in Neural Systems (BRAINS),Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Orlowski, Dariusz (författare)
- Aarhus University
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- Sørensen, Jens Christian H. (författare)
- Aarhus University
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- Doudet, Doris J. (författare)
- University of British Columbia
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- Landau, Anne M. (författare)
- Aarhus University Hospital,Aarhus University
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(creator_code:org_t)
- 2018-10-24
- 2018
- Engelska.
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Impairment of the ubiquitin proteasome system has been implicated in Parkinson’s disease. We used positron emission tomography to investigate longitudinal effects of chronic intracerebroventricular exposure to the proteasome inhibitor lactacystin on monoaminergic projections and neuroinflammation. Göttingen minipigs were implanted in the cisterna magna with a catheter connected to a subcutaneous injection port. Minipigs were imaged at baseline and after cumulative doses of 200 and 400 μg lactacystin, respectively. Main radioligands included [11C]-DTBZ (vesicular monoamine transporter type 2) and [11C]-yohimbine (α2-adrenoceptor). [11C]-DASB (serotonin transporter) and [11C]-PK11195 (activated microglia) became available later in the study and we present their results in a smaller subset of animals for information purposes only. Striatal [11C]-DTBZ binding potentials decreased significantly by 16% after 200 μg compared to baseline, but the decrease was not sustained after 400 μg (n = 6). [11C]-yohimbine volume of distribution increased by 18–25% in the pons, grey matter and the thalamus after 200 μg, which persisted at 400 μg (n = 6). In the later subset of minipigs, we observed decreased [11C]-DASB (n = 5) and increased [11C]-PK11195 (n = 3) uptake after 200 μg. These changes may mimic monoaminergic changes and compensatory responses in early Parkinson’s disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Lillethorup, The ...
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Glud, Andreas N.
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Alstrup, Aage K. ...
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Noer, Ove
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Nielsen, Erik H. ...
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Schacht, Anna C.
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visa fler...
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Landeck, Natalie
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Kirik, Deniz
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Orlowski, Darius ...
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Sørensen, Jens C ...
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Doudet, Doris J.
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Landau, Anne M.
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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och Neurologi
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