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Early Metabolic Mar...
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Ferrannini, Ele
(författare)
Early Metabolic Markers of the Development of Dysglycemia and Type 2 Diabetes and Their Physiological Significance
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
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2013-04-16
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American Diabetes Association,2013
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:2bc1b82d-9973-4fe2-8f5d-ad2b7f748b19
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https://lup.lub.lu.se/record/3843378URI
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https://doi.org/10.2337/db12-0707DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Metabolomic screening of fasting plasma from nondiabetic subjects identified alpha-hydroxybutyrate (alpha-HB) and linoleoyl-glycerophosphocholine (L-GPC) as joint markers of insulin resistance (IR) and glucose intolerance. To test the predictivity of alpha-HB and L-GPC for incident dysglycemia, alpha-HB and L-GPC measurements were obtained in two observational cohorts, comprising 1,261 nondiabetic participants from the Relationship between Insulin Sensitivity and Cardiovascular Disease (RISC) study and 2,580 from the Botnia Prospective Study, with 3-year and 9.5-year follow-up data, respectively. In both cohorts, alpha-HB was a positive correlate and L-GPC a negative correlate of insulin sensitivity, with alpha-HB reciprocally related to indices of beta-cell function derived from the oral glucose tolerance test (OGTT). In follow-up, alpha-HB was a positive predictor (adjusted odds ratios 1.25 [95% CI 1.00-1.60] and 1.26 [1.07-1.48], respectively, for each standard deviation of predictor), and L-GPC was a negative predictor (0.64 [0.48-0.85] and 0.67 [0.54-0.84]) of dysglycemia (RISC) or type 2 diabetes (Botnia), independent of familial diabetes, sex, age, BMI, and fasting glucose. Corresponding areas under the receiver operating characteristic curve were 0.791 (RISC) and 0.783 (Botnia), similar in accuracy when substituting cc-JIB and L-GPC with 2-h OGTT glucose concentrations. When their activity was examined, alpha-JIB inhibited and L-GPC stimulated glucose-induced insulin release in INS-le cells. alpha-JIB and L-GPC are independent predictors of worsening glucose tolerance, physiologically consistent with a joint signature of IR and beta-cell dysfunction. Diabetes 62:1730-1737, 2013
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Natali, Andrea
(författare)
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Camastra, Stefania
(författare)
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Nannipieri, Monica
(författare)
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Mari, Andrea
(författare)
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Adam, Klaus-Peter
(författare)
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Milburn, Michael V.
(författare)
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Kastemmueller, Gabi
(författare)
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Adamski, Jerzy
(författare)
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Tuomi, Tiinamaija
(författare)
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Lyssenko, ValeriyaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-vly
(författare)
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Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr
(författare)
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Gall, Walter E.
(författare)
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Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Diabetes: American Diabetes Association62:5, s. 1730-17371939-327X0012-1797
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Diabetes
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Ferrannini, Ele
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Natali, Andrea
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Camastra, Stefan ...
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Nannipieri, Moni ...
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Mari, Andrea
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Adam, Klaus-Pete ...
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visa fler...
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Milburn, Michael ...
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Kastemmueller, G ...
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Adamski, Jerzy
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Tuomi, Tiinamaij ...
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Lyssenko, Valeri ...
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Groop, Leif
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Gall, Walter E.
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