Sökning: onr:"swepub:oai:lup.lub.lu.se:2e2272eb-3eb0-4776-8f9b-c038cb8f63d7" > Dendritic cell migr...
Fältnamn | Indikatorer | Metadata |
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000 | 04245naa a2200517 4500 | |
001 | oai:lup.lub.lu.se:2e2272eb-3eb0-4776-8f9b-c038cb8f63d7 | |
003 | SwePub | |
008 | 180301s2018 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/2e2272eb-3eb0-4776-8f9b-c038cb8f63d72 URI |
024 | 7 | a https://doi.org/10.3389/fimmu.2018.002062 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Nadafi, Rezau Amsterdam UMC - Vrije Universiteit Amsterdam4 aut |
245 | 1 0 | a Dendritic cell migration to skin-draining lymph nodes is controlled by dermatan sulfate and determines adaptive immunity magnitude |
264 | c 2018-02-08 | |
264 | 1 | b Frontiers Media SA,c 2018 |
520 | a For full activation of naïve adaptive lymphocytes in skin-draining lymph nodes (LNs), presentation of peptide:MHC complexes by LN-resident and skin-derived dendritic cells (DCs) that encountered antigens (Ags) is an absolute prerequisite. To get to the nearest draining LN upon intradermal immunization, DCs need to migrate from the infection site to the afferent lymphatics, which can only be reached by traversing a collagen-dense network located in the dermis of the skin through the activity of proteolytic enzymes. Here, we show that mice with altered collagen fibrillogenesis resulting in thicker collagen fibers in the skin display a reduced DC migration to the draining LN upon immune challenge. Consequently, the initiation of the cellular and humoral immune response was diminished. Ag-specific CD8+ and CD4+ T cells as well as Ag-specific germinal center B cells and serum immunoglobulin levels were significantly decreased. Hence, we postulate that alterations to the production of extracellular matrix, as seen in various connective tissue disorders, may in the end affect the qualitative outcome of adaptive immunity. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
653 | a Adaptive immunity | |
653 | a Antigen | |
653 | a Collagen | |
653 | a Dendritic cells | |
653 | a Dermatan sulfate epimerase | |
653 | a Dse | |
653 | a Ehlers-Danlos syndrome | |
653 | a Skin-draining lymph node | |
700 | 1 | a Koning, Jasper J.u Amsterdam UMC - Vrije Universiteit Amsterdam4 aut |
700 | 1 | a Veninga, Henrikeu Amsterdam UMC - Vrije Universiteit Amsterdam4 aut |
700 | 1 | a Stachtea, Xanthi N.u Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine4 aut0 (Swepub:lu)med-xis |
700 | 1 | a Konijn, Tanjau Amsterdam UMC - Vrije Universiteit Amsterdam4 aut |
700 | 1 | a Zwiers, Antonieu Amsterdam UMC - Vrije Universiteit Amsterdam4 aut |
700 | 1 | a Malmström, Andersu Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine4 aut0 (Swepub:lu)medk-ama |
700 | 1 | a den Haan, Joke M.M.u Amsterdam UMC - Vrije Universiteit Amsterdam4 aut |
700 | 1 | a Mebius, Reina E.u Amsterdam UMC - Vrije Universiteit Amsterdam4 aut |
700 | 1 | a Maccarana, Marcou Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine4 aut0 (Swepub:lu)medk-mm0 |
700 | 1 | a Reijmers, Rogier M.u Amsterdam UMC - Vrije Universiteit Amsterdam4 aut |
710 | 2 | a Amsterdam UMC - Vrije Universiteit Amsterdamb Institutionen för experimentell medicinsk vetenskap4 org |
773 | 0 | t Frontiers in Immunologyd : Frontiers Media SAg 9:FEBq 9:FEBx 1664-3224 |
856 | 4 | u http://dx.doi.org/10.3389/fimmu.2018.00206x freey FULLTEXT |
856 | 4 | u https://www.frontiersin.org/articles/10.3389/fimmu.2018.00206/pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/2e2272eb-3eb0-4776-8f9b-c038cb8f63d7 |
856 | 4 8 | u https://doi.org/10.3389/fimmu.2018.00206 |
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