Sökning: onr:"swepub:oai:lup.lub.lu.se:301e11f0-736a-4781-a5b4-929c72a80017" > Ring chromosomes, b...
Fältnamn | Indikatorer | Metadata |
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000 | 03713naa a2200433 4500 | |
001 | oai:lup.lub.lu.se:301e11f0-736a-4781-a5b4-929c72a80017 | |
003 | SwePub | |
008 | 160401s2015 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/48161882 URI |
024 | 7 | a https://doi.org/10.1002/gcc.222282 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Macchia, Gemma4 aut |
245 | 1 0 | a Ring chromosomes, breakpoint clusters, and neocentromeres in sarcomas. |
264 | c 2014-11-25 | |
264 | 1 | b Wiley,c 2015 |
520 | a Gene amplification is relatively common in tumors. In certain subtypes of sarcoma, it often occurs in the form of ring and/or giant rod-shaped marker (RGM) chromosomes whose mitotic stability is frequently rescued by ectopic novel centromeres (neocentromeres). Little is known about the origin and structure of these RGM chromosomes, including how they arise, their internal organization, and which sequences underlie the neocentromeres. To address these questions, 42 sarcomas with RGM chromosomes were investigated to detect regions prone to double strand breaks and possible functional or structural constraints driving the amplification process. We found nine breakpoint cluster regions potentially involved in the genesis of RGM chromosomes, which turned out to be significantly enriched in poly-pyrimidine traits. Some of the clusters were located close to genes already known to be relevant for sarcomas, thus indicating a potential functional constraint, while others mapped to transcriptionally inactive chromatin domains enriched in heterochromatic sites. Of note, five neocentromeres were identified after analyzing 13 of the cases by fluorescent in situ hybridization. ChIP-on-chip analysis with antibodies against the centromeric protein CENP-A showed that they were a patchwork of small genomic segments derived from different chromosomes, likely joint to form a contiguous sequence during the amplification process. © 2014 Wiley Periodicals, Inc. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Hansén Nord, Karolinu Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)klin-kha |
700 | 1 | a Zoli, Monica4 aut |
700 | 1 | a Purgato, Stefania4 aut |
700 | 1 | a D'Addabbo, Pietro4 aut |
700 | 1 | a Whelan, Christopher W4 aut |
700 | 1 | a Carbone, Lucia4 aut |
700 | 1 | a Perini, Giovanni4 aut |
700 | 1 | a Mertens, Fredriku Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-fme |
700 | 1 | a Rocchi, Mariano4 aut |
700 | 1 | a Storlazzi, Clelia Tiziana4 aut |
710 | 2 | a Avdelningen för klinisk genetikb Institutionen för laboratoriemedicin4 org |
773 | 0 | t Genes, Chromosomes and Cancerd : Wileyg 54:3, s. 156-167q 54:3<156-167x 1045-2257 |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/25421174?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1002/gcc.22228y FULLTEXT |
856 | 4 | u http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1098-2264 |
856 | 4 8 | u https://lup.lub.lu.se/record/4816188 |
856 | 4 8 | u https://doi.org/10.1002/gcc.22228 |
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