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Early Pregnancy Exp...
Early Pregnancy Exposure to Ambient Air Pollution among Late-Onset Preeclamptic Cases Is Associated with Placental DNA Hypomethylation of Specific Genes and Slower Placental Maturation
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- Engström, Karin (författare)
- Lund University,Lunds universitet,EPI@LUND,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Mandakh, Yumjirmaa (författare)
- Lund University,Lunds universitet,Planetär hälsa,Forskargrupper vid Lunds universitet,Planetary Health,Lund University Research Groups
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- Garmire, Lana (författare)
- University of Michigan
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- Masoumi, Zahra (författare)
- Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Isaxon, Christina (författare)
- Lund University,Lunds universitet,Metalund,Annan verksamhet, LTH,Lunds Tekniska Högskola,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,Other operations, LTH,Faculty of Engineering, LTH,Other operations, LTH,Faculty of Engineering, LTH,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH
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- Malmqvist, Ebba (författare)
- Lund University,Lunds universitet,Planetär hälsa,Forskargrupper vid Lunds universitet,Planetary Health,Lund University Research Groups
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- Erlandsson, Lena (författare)
- Lund University,Lunds universitet,Enheten för translationell obstetrisk forskning,Forskargrupper vid Lunds universitet,Unit for translational obstetric research,Lund University Research Groups
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- Hansson, Stefan (författare)
- Lund University,Lunds universitet,Enheten för translationell obstetrisk forskning,Forskargrupper vid Lunds universitet,Unit for translational obstetric research,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- 2021-12-06
- 2021
- Engelska.
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Ingår i: Toxics. - : MDPI AG. - 2305-6304. ; 9:12, s. 1-23
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.mdpi.com...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Exposure to ambient air pollution during pregnancy has been associated with an increased risk of preeclampsia (PE). Some suggested mechanisms behind this association are changes in placental DNA methylation and gene expression. The objective of this study was to identify how early pregnancy exposure to ambient nitrogen oxides (NOx) among PE cases and normotensive controls influence DNA methylation (EPIC array) and gene expression (RNA-seq). The study included placentas from 111 women (29 PE cases/82 controls) in Scania, Sweden. First-trimester NOx exposure was assessed at the participants’ residence using a dispersion model and categorized via median split into high or low NOx. Placental gestational epigenetic age was derived from the DNA methylation data. We identified six differentially methylated positions (DMPs, q < 0.05) comparing controls with low NOx vs. cases with high NOx and 14 DMPs comparing cases and controls with high NOx. Placentas with female fetuses showed more DMPs (N = 309) than male-derived placentas (N = 1). Placentas from PE cases with high NOx demonstrated gestational age deceleration compared to controls with low NOx (p = 0.034). No differentially expressed genes (DEGs, q < 0.05) were found. In conclusion, early pregnancy exposure to NOx affected placental DNA methylation in PE, resulting in placental immaturity and showing sexual dimorphism.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
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