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Sequential chemothe...
Sequential chemotherapy/radiotherapy was comparable with concurrent chemoradiotherapy for stage I/II NK/T-cell lymphoma
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- Kwong, Y. L. (författare)
- Queen Mary Hospital
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- Kim, S. J. (författare)
- Sungkyunkwan University
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- Tse, E. (författare)
- Queen Mary Hospital
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- Oh, S. Y. (författare)
- Dong-a University Hospital
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- Kwak, J. Y. (författare)
- Chonbuk National University
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- Eom, H. S. (författare)
- National Cancer Center, Gyeonggi
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- Do, Y. R. (författare)
- Keimyung University
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- Mun, Y. C. (författare)
- Ewha Womans University Mokdong Hospital
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- Lee, S. R. (författare)
- Korea University Ansan Hospital
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- Shin, H. J. (författare)
- Pusan National University Yangsan Hospital
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Suh, C. (författare)
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Chuang, S. S. (författare)
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- Lee, Y. S. (författare)
- Singapore General Hospital
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- Lim, S. T. (författare)
- National Cancer Centre Singapore
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Izutsu, K. (författare)
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- Suzuki, R. (författare)
- Shimane University
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- Relander, T. (författare)
- Lund University,Lunds universitet,Skåne University Hospital
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- d'Amore, F. (författare)
- Aarhus University Hospital
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- Schmitz, N. (författare)
- Asklepios Klinik St. Georg
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- Jaccard, A. (författare)
- University Hospital Of Limoges
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- Kim, W. S. (författare)
- Sungkyunkwan University
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska.
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Ingår i: Annals of Oncology. - : Elsevier BV. - 0923-7534. ; 29:1, s. 256-263
- Relaterad länk:
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http://dx.doi.org/10...
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http://www.annalsofo...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: In stage I/II natural killer (NK)/T-cell lymphoma, concurrent chemoradiotherapy (CCRT) had previously been shown to result in superior outcome compared with anthracycline-containing regimens, which have since been considered ineffective. The role of CCRT in comparison with approaches employing nonanthracycline-containing chemotherapy (CT) and sequential radiotherapy (RT) in such patients remains to be defined. Patients and methods: Three hundred and three untreated patients (207 men, 96 women; median age: 51, 18-86 years) with stage I/II NK/T-cell lymphoma who had received nonanthracycline-containing regimens were collected from an international consortium and retrospectively analyzed. Treatment included single modality (CT and RT), sequential modalities (CT+RT; RT+CT) and concurrent modalities (CCRT; CCRT+CT). The impact of clinicopathologic parameters and types of treatment on complete response (CR) rate, progression-free-survival (PFS) and overall-survival (OS) was evaluated. Results: For CR, stage (P=0.027), prognostic index for NK/T-cell lymphoma (PINK) (P=0.026) and types of initial treatment (P=0.011) were significant prognostic factors on multivariate analysis. On Cox regression analysis, ECOG performance score (P=0.021) and PINK-EBV DNA (PINK-E) (P=0.002) significantly impacted on PFS; whereas ECOG performance score (P=0.008) and stage (P<0.001) significantly impacted on OS. For comparing CCRT6CT and sequential CT+RT, CCRT6CT patients (n=190) were similar to sequential CT+RT patients (n=54) in all evaluated clinicopathologic parameters except two significantly superior features (higher proportion of undetectable circulating EBV DNA on diagnosis and lower PINK-E scores). Despite more favorable pre-treatment characteristics, CCRT6CT patients had CR rate, PFS and OS comparable with sequential CT+RT patients on multivariate and Cox regression analyses. Conclusions: In stage I/II NK/T-cell lymphomas, when effective chemotherapeutic regimens were used, CCRT and sequential CT+RT gave similar outcome.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Concurrent chemoradiotherapy
- Sequential chemotherapy and radiotherapy
- Stage I/II NK/T-cell lymphomas
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Till lärosätets databas
- Av författaren/redakt...
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Kwong, Y. L.
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Kim, S. J.
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Tse, E.
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Oh, S. Y.
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Kwak, J. Y.
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Eom, H. S.
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visa fler...
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Do, Y. R.
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Mun, Y. C.
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Lee, S. R.
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Shin, H. J.
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Suh, C.
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Chuang, S. S.
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Lee, Y. S.
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Lim, S. T.
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Izutsu, K.
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Suzuki, R.
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Relander, T.
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d'Amore, F.
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Schmitz, N.
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Jaccard, A.
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Kim, W. S.
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