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Patient-Reported Ou...
Patient-Reported Outcomes (PROs) and PRO Remission Rates in 12,262 Biologic-Naive Patients With Psoriatic Arthritis Treated With Tumor Necrosis Factor Inhibitors in Routine Care
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- Ornbjerg, Lykke M. (författare)
- Copenhagen University Hospital
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- Rugbjerg, Kathrine (författare)
- Copenhagen University Hospital
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- Georgiadis, Stylianos (författare)
- Copenhagen University Hospital
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- Rasmussen, Simon H. (författare)
- Copenhagen University Hospital
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- Jacobsson, Lennart T. H., 1954 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Sahlgrenska Academy
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- Loft, Anne G. (författare)
- Aarhus University Hospital
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- Iannone, Florenzo (författare)
- University of Bari Aldo Moro
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- Fagerli, Karen M. (författare)
- Diakonhjemmet Hospital
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- Vencovsky, Jiri (författare)
- Charles University in Prague
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- Santos, Maria J. (författare)
- Hospital Garcia de Orta
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- Moeller, Burkhard (författare)
- Bern University Hospital
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- Pombo-Suarez, Manuel (författare)
- Complejo Hospitalario Universitario de Santiago
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- Rotar, Ziga (författare)
- University Medical Centre Ljubljana,University of Ljubljana
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- Gudbjornsson, Bjorn (författare)
- National University Hospital of Iceland
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- Cefle, Ayse (författare)
- Kocaeli University
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- Eklund, Kari (författare)
- Helsinki University Central Hospital
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- Codreanu, Catalin (författare)
- Carol Davila University of Medicine and Pharmacy
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Jones, Gareth (författare)
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- van der Sande, Marleen (författare)
- University of Amsterdam
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- Wallman, Johan K. (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund Arthritis Research Group (LARG),Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital
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- Sebastiani, Marco (författare)
- University of Modena and Reggio Emilia
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- Michelsen, Brigitte (författare)
- Sørlandet Hospital,Copenhagen University Hospital,Diakonhjemmet Hospital
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- Zavada, Jakub (författare)
- Charles University in Prague
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- Nissen, Michael J. (författare)
- Geneva University Hospital
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- Sanchez-Piedra, Carlos (författare)
- Carlos III Health Institute
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- Tomsic, Matija (författare)
- University Medical Centre Ljubljana,University of Ljubljana
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- Love, Thorvardur J. (författare)
- University of Iceland
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- Relas, Heikki (författare)
- Helsinki University Central Hospital
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- Mogosan, Corina (författare)
- Carol Davila University of Medicine and Pharmacy
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- Hetland, Merete L. (författare)
- Copenhagen University Hospital,University of Copenhagen
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- Ostergaard, Mikkel (författare)
- Copenhagen University Hospital,University of Copenhagen
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: JOURNAL OF RHEUMATOLOGY. - 0315-162X .- 1499-2752. ; 51:4, s. 378-389
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Objective. To evaluate patient-reported outcomes (PROs) after initiation of tumor necrosis factor inhibitor (TNFi) treatment in European real-world patients with psoriatic arthritis (PsA). Further, to investigate PRO remission rates across treatment courses, registries, disease duration, sex, and age at disease onset. Methods. Visual analog scale or numerical rating scale scores for pain, fatigue, patient global assessment (PtGA), and the Health Assessment Questionnaire-Disability Index (HAQ-DI) from 12,262 patients with PsA initiating a TNFi in 13 registries were pooled. PRO remission rates (pain <= 1, fatigue <= 2, PtGA <= 2, and HAQ-DI <= 0.5) were calculated for patients still on the treatment. Results. For the first TNFi, median pain score was reduced by approximately 50%, from 6 to 3, 3, and 2; as were fatigue scores, from 6 to 4, 4, and 3; PtGA scores, from 6 to 3, 3, and 2; and HAQ-DI scores, from 0.9 to 0.5, 0.5, and 0.4 at baseline, 6, 12, and 24 months, respectively. Six-month Lund Efficacy Index (LUNDEX)-adjusted remission rates for pain, fatigue, PtGA, and HAQ-DI scores were 24%, 31%, 36%, and 43% (first TNFi); 14%, 19%, 23%, and 29% (second TNFi); and 9%, 14%, 17%, and 20% (third TNFi), respectively. For biologic-naive patients with disease duration < 5 years, 6-month LUNDEX-adjusted remission rates for pain, fatigue, PtGA, and HAQ-DI scores were 22%, 28%, 33%, and 42%, respectively. Corresponding rates for patients with disease duration > 10 years were 27%, 32%, 41%, and 43%, respectively. Remission rates were 33%, 40%, 45%, and 56% for men and 17%, 23%, 24%, and 32% for women, respectively. For patients aged < 45 years at diagnosis, 6-month LUNDEX-adjusted remission rate for pain was 29% vs 18% for patients >= 45 years. Conclusion. In 12,262 biologic-na & iuml;ve patients with PsA, 6 months of treatment with a TNFi reduced pain by approximately 50%. Marked differences in PRO remission rates across treatment courses, registries, disease duration, sex, and age at onset of disease were observed, emphasizing the potential influence of factors other than disease activity on PROs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- epidemiology
- fatigue
- pain
- psoriatic arthritis
- tumor necrosis factor inhibitors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Ornbjerg, Lykke ...
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Rugbjerg, Kathri ...
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Georgiadis, Styl ...
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Rasmussen, Simon ...
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Jacobsson, Lenna ...
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Loft, Anne G.
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Iannone, Florenz ...
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Fagerli, Karen M ...
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Vencovsky, Jiri
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Santos, Maria J.
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Moeller, Burkhar ...
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Pombo-Suarez, Ma ...
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Rotar, Ziga
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Gudbjornsson, Bj ...
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Cefle, Ayse
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Eklund, Kari
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Codreanu, Catali ...
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Jones, Gareth
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van der Sande, M ...
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Wallman, Johan K ...
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Sebastiani, Marc ...
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Michelsen, Brigi ...
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Zavada, Jakub
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Nissen, Michael ...
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Sanchez-Piedra, ...
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Tomsic, Matija
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Love, Thorvardur ...
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Relas, Heikki
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Mogosan, Corina
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Hetland, Merete ...
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Ostergaard, Mikk ...
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Göteborgs universitet
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