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Effect of cholester...
Effect of cholesterol on the lateral nanoscale dynamics of fluid membranes
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Armstrong, Clare L. (författare)
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Barrett, Matthew A. (författare)
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- Hiess, Arno (författare)
- Lund University,Lunds universitet,European Spallation Source ESS AB,Stiftelser och övriga anknutna verksamheter,Other Institutions and Utilities
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Salditt, Tim (författare)
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Katsaras, John (författare)
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Shi, An-Chang (författare)
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Rheinstaedter, Maikel C. (författare)
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(creator_code:org_t)
- 2012-06-23
- 2012
- Engelska.
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Ingår i: European Biophysics Journal. - : Springer Science and Business Media LLC. - 0175-7571 .- 1432-1017. ; 41:10, s. 901-913
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Inelastic neutron scattering was used to study the effect of 5 and 40 mol% cholesterol on the lateral nanoscale dynamics of phospholipid membranes. By measuring the excitation spectrum at several lateral q (||) values (up to q (||) = 3 (-1)), complete dispersion curves were determined of gel, fluid and liquid-ordered phase bilayers. The inclusion of cholesterol had a distinct effect on the collective dynamics of the bilayer's hydrocarbon chains; specifically, we observed a pronounced stiffening of the membranes on the nanometer length scale in both gel and fluid bilayers, even though they were experiencing a higher degree of molecular disorder. Also, for the first time we determined the nanoscale dynamics in the high-cholesterol liquid-ordered phase of bilayers containing cholesterol. Namely, this phase appears to be "softer" than fluid bilayers, but better ordered than bilayers in the gel phase.
Ämnesord
- NATURVETENSKAP -- Fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences (hsv//eng)
Nyckelord
- Lipid membrane
- Cholesterol
- Lateral membrane dynamics
- Nanoscale
- dynamics
- Liquid-ordered phase
- Inelastic neutron scattering
- Dispersion
- relation
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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