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Platelets in ITP : ...
Platelets in ITP : Victims in charge of their own fate?
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- Nelson, Vivianne S. (författare)
- Haga Teaching Hospital,Academic Medical Center of University of Amsterdam (AMC)
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- Jolink, Anne Tess C. (författare)
- Academic Medical Center of University of Amsterdam (AMC)
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- Amini, Sufia N. (författare)
- Haga Teaching Hospital,Leiden University Medical Centre
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- Zwaginga, Jaap Jan (författare)
- Sanquin Blood Supply,Leiden University Medical Centre
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- Netelenbos, Tanja (författare)
- Haga Teaching Hospital
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- Semple, John W. (författare)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Trombocyt immunologi,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Platelet Immunology,Lund University Research Groups
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- Porcelijn, Leendert (författare)
- Sanquin Diagnostic Services
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- de Haas, Masja (författare)
- Academic Medical Center of University of Amsterdam (AMC),Sanquin Diagnostic Services,Leiden University Medical Centre
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- Schipperus, Martin R. (författare)
- University Medical Center Groningen
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- Kapur, Rick (författare)
- University of Amsterdam
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(creator_code:org_t)
- 2021-11-19
- 2021
- Engelska.
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Ingår i: Cells. - : MDPI AG. - 2073-4409. ; 10:11
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.mdpi.com...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder. The pathophysiological mechanisms leading to low platelet levels in ITP have not been resolved, but at least involve autoantibody-dependent and/or cytotoxic T cell mediated platelet clearance and impaired megakary-opoiesis. In addition, T cell imbalances involving T regulatory cells (Tregs) also appear to play an important role. Intriguingly, over the past years it has become evident that platelets not only mediate hemostasis, but are able to modulate inflammatory and immunological processes upon activation. Platelets, therefore, might play an immuno-modulatory role in the pathogenesis and pathophysiology of ITP. In this respect, we propose several possible pathways in which platelets themselves may participate in the immune response in ITP. First, we will elaborate on how platelets might directly promote inflammation or stimulate immune responses in ITP. Second, we will discuss two ways in which platelet microparticles (PMPs) might contribute to the disrupted immune balance and impaired thrombopoiesis by megakaryocytes in ITP. Importantly, from these insights, new starting points for further research and for the design of potential future therapies for ITP can be envisioned.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- ITP
- Platelet immune functions
- Platelet microparticles
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Till lärosätets databas
- Av författaren/redakt...
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Nelson, Vivianne ...
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Jolink, Anne Tes ...
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Amini, Sufia N.
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Zwaginga, Jaap J ...
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Netelenbos, Tanj ...
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Semple, John W.
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visa fler...
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Porcelijn, Leend ...
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de Haas, Masja
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Schipperus, Mart ...
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Kapur, Rick
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
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Cells
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Lunds universitet