Sökning: onr:"swepub:oai:lup.lub.lu.se:3830d661-1e95-4434-aedb-7be2b332bb36" >
Decreased CSF oxyto...
Decreased CSF oxytocin relates to measures of social cognitive impairment in Huntington's disease patients
-
- Hellem, Marie N.N. (författare)
- Copenhagen University Hospital
-
- Cheong, Rachel Y. (författare)
- Lund University,Lunds universitet,Brain Repair and Imaging in Neural Systems (BRAINS),Forskargrupper vid Lunds universitet,Lund University Research Groups
-
- Tonetto, Simone (författare)
- Lund University,Lunds universitet,Translationell neuroendokrinologi,Forskargrupper vid Lunds universitet,Translational Neuroendocrinology,Lund University Research Groups
-
visa fler...
-
- Vinther-Jensen, Tua (författare)
- Copenhagen University Hospital,Frederiksberg Hospital
-
- Hendel, Rebecca K. (författare)
- University of Copenhagen,Copenhagen University Hospital
-
- Larsen, Ida U. (författare)
- Frederiksberg Hospital
-
- Nielsen, Troels T. (författare)
- Copenhagen University Hospital
-
- Hjermind, Lena E. (författare)
- Copenhagen University Hospital
-
- Vogel, Asmus (författare)
- Copenhagen University Hospital,University of Copenhagen
-
- Budtz-Jørgensen, Esben (författare)
- University of Copenhagen
-
- Petersén, Åsa (författare)
- Lund University,Lunds universitet,Translationell neuroendokrinologi,Forskargrupper vid Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Translational Neuroendocrinology,Lund University Research Groups,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Nielsen, Jørgen E. (författare)
- Copenhagen University Hospital
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- Engelska 7 s.
-
Ingår i: Parkinsonism and Related Disorders. - : Elsevier BV. - 1353-8020. ; 99, s. 23-29
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objective: Huntington's disease (HD) is an inherited neurodegenerative disease with motor, cognitive and psychiatric symptoms. Non-motor symptoms like depression and altered social cognition are proposed to be caused by dysfunction of the hypothalamus. We measured the hypothalamic neuropeptide oxytocin in plasma and cerebrospinal fluid (CSF) in a cohort of HD gene expansion carriers (HDGECs), compared the levels to healthy HD family controls and correlated oxytocin levels to disease progression and social cognition. Methods: We recruited 113 HDGECs and 33 controls. Psychiatric and cognitive symptoms were evaluated, and social cognition was assessed with the Emotion Hexagon test, Reading the Mind in the Eyes and The Awareness of Social Inference Test. The levels of oxytocin in CSF and blood were analyzed by radioimmunoassay. Results: We found the level of oxytocin in CSF to be significantly lower by 33.5% in HDGECs compared to controls (p = 0.016). When dividing the HDGECs into groups with or without cognitive impairment, we found the oxytocin level to be significantly lower by 30.3% in the HDGECs with cognitive symptoms (p = 0.046). We found a statistically significant correlation between the level of oxytocin and scores on social cognition (Reading the Mind in the Eyes p = 0.0019; Emotion Hexagon test: p = 0.0062; The Awareness of Social Inference Test: p = 0.002). Conclusions: This is the first study to measure oxytocin in the CSF of HDGECs. We find that HDGECs have a significantly lower level of oxytocin compared to controls, and that the level of oxytocin may represent an objective and comparable measure that could be used as a state biomarker for impairment of social cognition. We suggest treatment trials to evaluate a potential effect of oxytocin on social cognition in HD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Huntington's disease
- Neuroendocrinology
- Oxytocin
- Social cognition
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Hellem, Marie N. ...
-
Cheong, Rachel Y ...
-
Tonetto, Simone
-
Vinther-Jensen, ...
-
Hendel, Rebecca ...
-
Larsen, Ida U.
-
visa fler...
-
Nielsen, Troels ...
-
Hjermind, Lena E ...
-
Vogel, Asmus
-
Budtz-Jørgensen, ...
-
Petersén, Åsa
-
Nielsen, Jørgen ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Neurovetenskaper
- Artiklar i publikationen
-
Parkinsonism and ...
- Av lärosätet
-
Lunds universitet