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FältnamnIndikatorerMetadata
00005963naa a2200433 4500
001oai:lup.lub.lu.se:39208f8d-a58b-4aa0-9a84-b002dc86986a
003SwePub
008240426s2024 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:155381405
009oai:DiVA.org:uu-528265
0247 a https://lup.lub.lu.se/record/39208f8d-a58b-4aa0-9a84-b002dc86986a2 URI
0247 a https://doi.org/10.1155/2024/22415282 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1553814052 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5282652 URI
040 a (SwePub)lud (SwePub)kid (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Gilje, Patriku Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Cardiol, Lund, Sweden.4 aut0 (Swepub:lu)med-pae
2451 0a A Single High-Sensitivity Cardiac Troponin T Strategy for Ruling Out Myocardial Infarction
264 1b Hindawi Publishing Corporation,c 2024
520 a Background. Ruling out acute myocardial infarction (AMI) in the emergency department (ED) is challenging. Studies have shown that a high-sensitivity cardiac troponin T (hs-cTnT) <5 ng/L or <6 ng/L at presentation (0 h) can be used to rule out AMI. The objective of this study was to identify whether an even higher hs-cTnT threshold can be used for a safe rule out of AMI in the ED. Methods. The derivation cohort consisted of 24,973 ED patients with a primary complaint of chest pain. In this cohort, we identified the highest concentration of 0 h hs-cTnT that corresponded to a negative predictive value (NPV) of ≥99.5% for the primary endpoint of AMI/all-cause death within 30 days and the secondary endpoint of all-cause death within one year. The results were validated in two cohorts consisting of 132,021 and 1167 ED chest pain patients. Results. The 0 h hs-cTnT threshold corresponding to a NPV of ≥99.5% for the primary endpoint was <9 ng/L (NPV: 99.6% and 95% CI: 99.5-99.7). This cutoff provided a sensitivity of 96.2% (95% CI: 95.2-97.1) and identified 59.7% of the patients as low risk compared to 35.8% and 43.9% with a 0 h hs-cTnT <5 ng/L and <6 ng/L, respectively. The results were similar in the validation cohorts and seemed to perform even better in patients where the 0 h hs-cTnT was measured >3 h after symptom onset and in those with a nonischemic ECG and nonhigh risk history. Conclusions. A 0 h hs-cTnT cutoff of <9 ng/L safely rules out AMI/death within 30 days in a majority of chest pain patients and is a more effective strategy than the currently recommended <5 ng/L and <6 ng/L cutoffs. This trial is registered with NCT03421873.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
7001 a Mohammad, Moman A.u Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Cardiol, Lund, Sweden.4 aut0 (Swepub:lu)med-mm11
7001 a Roos, Andreasu Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Dept Med, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Emergency & Reparat Med, Stockholm, Sweden.4 aut
7001 a Ekelund, Ulfu Lund University,Lunds universitet,Akutsjukvård,Forskargrupper vid Lunds universitet,Emergency medicine,Lund University Research Groups,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Internal & Emergency Med, Lund, Sweden.4 aut0 (Swepub:lu)mphy-uek
7001 a Björk, Jonasu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,EPI@LUND,Forskargrupper vid Lunds universitet,LU profilområde: Naturbaserade framtidslösningar,Lunds universitets profilområden,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups,LU Profile Area: Nature-based future solutions,Lund University Profile areas,Lund Univ, Occupat & Environm Med, Lund, Sweden.4 aut0 (Swepub:lu)ymed-jbj
7001 a Lindahl, Bertil,d 1957-u Uppsala universitet,Uppsala University,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)belin227
7001 a Holzmann, Martinu Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Dept Med, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Emergency & Reparat Med, Stockholm, Sweden.4 aut
7001 a Mokhtari, Arashu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,NPWT teknologin,Forskargrupper vid Lunds universitet,Skonsammare hjärtkirurgi,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,NPWT technology,Lund University Research Groups,Less invasive cardiac surgery,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Cardiol, Lund, Sweden.4 aut0 (Swepub:lu)thor-ami
7102 a Molekylär kardiologib Forskargrupper vid Lunds universitet4 org
7730 t Emergency Medicine Internationald : Hindawi Publishing Corporationg 2024q 2024x 2090-2840x 2090-2859
8564 u http://dx.doi.org/10.1155/2024/2241528x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/39208f8d-a58b-4aa0-9a84-b002dc86986a
8564 8u https://doi.org/10.1155/2024/2241528
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:155381405
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-528265

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