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Retinal toxicity in...
Retinal toxicity in a multinational inception cohort of patients with systemic lupus on hydroxychloroquine
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- Almeida-Brasil, Celline C. (författare)
- McGill University Health Center
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- Hanly, John G. (författare)
- Dalhousie University
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- Urowitz, Murray (författare)
- University of Toronto
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- Clarke, Ann Elaine (författare)
- Cumming School of Medicine
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- Ruiz-Irastorza, Guillermo (författare)
- Biocruces Bizkaia Health Research Institute
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- Gordon, Caroline (författare)
- University of Birmingham
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- Ramsey-Goldman, Rosalind (författare)
- Northwestern University
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- Petri, Michelle A. (författare)
- Johns Hopkins University School of Medicine
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- Ginzler, Ellen M. (författare)
- SUNY Downstate Health Sciences University
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- Wallace, Daniel J. (författare)
- Cedars-Sinai Medical Center
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- Bae, Sang Cheol (författare)
- Hanyang University Hospital for Rheumatic Disease
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- Romero-Diaz, Juanita (författare)
- Salvador Zubirán National Institute of Health Sciences and Nutrition
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- Dooley, Mary Anne (författare)
- University of North Carolina
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- Peschken, Christine (författare)
- University of Manitoba
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- Isenberg, David (författare)
- University College London
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- Rahman, Anisur (författare)
- University College London
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- Manzi, Susan (författare)
- Allegheny Health Network
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- Jacobsen, Søren (författare)
- Copenhagen University Hospital
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- Sam Lim, S. (författare)
- Emory University
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- Van Vollenhoven, Ronald (författare)
- Amsterdam Rheumatology and Immunology Center
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- Nived, Ola (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Jönsen, Andreas (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Kamen, Diane L. (författare)
- Medical University of South Carolina
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- Aranow, Cynthia (författare)
- Feinstein Institute for Medical Research
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- Sánchez-Guerrero, Jorge (författare)
- Toronto Western Hospital
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- Gladman, Dafna D. (författare)
- Toronto Western Hospital
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- Fortin, Paul R. (författare)
- Laval University
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- Alarcon, Graciela S. (författare)
- University of Alabama
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- Merrill, Joan T. (författare)
- Oklahoma Medical Research Foundation
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- Kalunian, Kenneth (författare)
- University of California, San Diego
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- Ramos-Casals, Manuel (författare)
- University of Barcelona
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- Steinsson, Kristjan (författare)
- National University Hospital of Iceland
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- Zoma, A. (författare)
- Hairmyres Hospital
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- Askanase, Anca D. (författare)
- Columbia University
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- Khamashta, Munther (författare)
- St Thomas' Hospital
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- Bruce, Ian N. (författare)
- University of Manchester
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- Inanc, Murat (författare)
- Istanbul University
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- Lukusa, Luck (författare)
- McGill University Health Center
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- Bernatsky, Sasha (författare)
- McGill University Health Center
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(creator_code:org_t)
- 2022-11-17
- 2022
- Engelska.
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Ingår i: Lupus Science and Medicine. - : BMJ. - 2053-8790. ; 9:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective To evaluate hydroxychloroquine (HCQ)-related retinal toxicity in the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort. Methods Data were collected at annual study visits between 1999 and 2019. We followed patients with incident SLE from first visit on HCQ (time zero) up to time of retinal toxicity (outcome), death, loss-to-follow-up or end of study. Potential retinal toxicity was identified from SLICC Damage Index scores; cases were confirmed with chart review. Using cumulative HCQ duration as the time axis, we constructed univariate Cox regression models to assess if covariates (ie, HCQ daily dose/kg, sex, race/ethnicity, age at SLE onset, education, body mass index, renal damage, chloroquine use) were associated with HCQ-related retinal toxicity. Results We studied 1460 patients (89% female, 52% white). Retinal toxicity was confirmed in 11 patients (incidence 1.0 per 1000 person-years, 0.8% overall). Average cumulative time on HCQ in those with retinal toxicity was 7.4 (SD 3.2) years; the first case was detected 4 years after HCQ initiation. Risk of retinal toxicity was numerically higher in older patients at SLE diagnosis (univariate HR 1.05, 95% CI 1.01 to 1.09). Conclusions This is the first assessment of HCQ and retinal disease in incident SLE. We did not see any cases of retinopathy within the first 4 years of HCQ. Cumulative HCQ may be associated with increased risk. Ophthalmology monitoring (and formal assessment of cases of potential toxicity, by a retinal specialist) remains important, especially in patients on HCQ for 10+ years, those needing higher doses and those of older age at SLE diagnosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- epidemiology
- health care
- lupus erythematosus
- outcome assessment
- systemic
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Almeida-Brasil, ...
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Hanly, John G.
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Urowitz, Murray
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Clarke, Ann Elai ...
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Ruiz-Irastorza, ...
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Gordon, Caroline
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visa fler...
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Ramsey-Goldman, ...
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Petri, Michelle ...
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Ginzler, Ellen M ...
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Wallace, Daniel ...
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Bae, Sang Cheol
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Romero-Diaz, Jua ...
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Dooley, Mary Ann ...
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Peschken, Christ ...
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Isenberg, David
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Rahman, Anisur
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Manzi, Susan
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Jacobsen, Søren
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Sam Lim, S.
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Van Vollenhoven, ...
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Nived, Ola
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Jönsen, Andreas
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Kamen, Diane L.
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Aranow, Cynthia
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Sánchez-Guerrero ...
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Gladman, Dafna D ...
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Fortin, Paul R.
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Alarcon, Graciel ...
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Merrill, Joan T.
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Kalunian, Kennet ...
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Ramos-Casals, Ma ...
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Steinsson, Krist ...
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Zoma, A.
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Askanase, Anca D ...
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Khamashta, Munth ...
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Bruce, Ian N.
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Inanc, Murat
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Lukusa, Luck
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Bernatsky, Sasha
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