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Biological and stru...
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Van Der Laan, Eveline A.N.ZeeuwSanquin Research,Academic Medical Center of University of Amsterdam (AMC)
(författare)
Biological and structural characterization of murine TRALI antibody reveals increased Fc-mediated complement activation
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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2020-08-18
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American Society of Hematology,2020
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11 s.
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:3a0643d4-5b43-4441-8429-029e5e3337b5
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https://lup.lub.lu.se/record/3a0643d4-5b43-4441-8429-029e5e3337b5URI
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https://doi.org/10.1182/bloodadvances.2020002291DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Transfusion-related acute lung injury (TRALI) remains a leading cause of transfusionrelated deaths. In most cases, anti-leukocyte antibodies in the transfusion product trigger TRALI, but not all anti-leukocyte antibodies cause TRALI. It has been shown that the anti-major histocompatibility complex (MHC) class I antibody 34-1-2S (anti-H-2Kd) causes TRALI in BALB/c mice (MHC class I haplotype H-2Kd), whereas SF1.1.10 (anti-H-2Kd) does not. In C57BL/6 mice (MHC class I haplotype H-2Kb), TRALI only occurs when anti-MHC class I antibody AF6-88.5.5.3 (anti-H-2Kb) is administered together with a high dose of 34-1-2S. It remains unknown which specific antibody characteristics are responsible for eliciting TRALI. We therefore investigated several biological and structural features of 34-1-2S compared with other anti-MHC class I antibodies, which on their own do not cause TRALI: SF1.1.10 and AF6-88.5.5.3. No substantial differences were observed between the TRALIcausing 34-1-2S and the TRALI-resistant SF1.1.10 regarding binding affinity to H-2Kd. Regarding binding affinity to H-2Kb, only AF6-88.5.5.3 potently bound to H-2Kb, whereas 34-1-2S exhibited weak but significant cross-reactivity. Furthermore, the binding affinity to FcgRs as well as the Fc glycan composition seemed to be similar for all antibodies. Similar Fc glycosylation profiles were also observed for human TRALI-causing donor anti-HLA antibodies compared with human anti-HLA antibodies from control donors. 34-1-2S, however, displayed superior complement activation capacity, which was fully Fc dependent and not significantly dependent on Fc glycosylation. We conclude that TRALI induction is not correlated with Fab- A nd Fc-binding affinities for antigen and FcgRs, respectively, nor with the composition of Fc glycans; but increased Fc-mediated complement activation is correlated with TRALI induction.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Van Der Velden, SaskiaAcademic Medical Center of University of Amsterdam (AMC),Sanquin Research
(författare)
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Bentlage, Arthur E.H.Sanquin Research,Academic Medical Center of University of Amsterdam (AMC)
(författare)
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Larsen, Mads D.Academic Medical Center of University of Amsterdam (AMC),Sanquin Research
(författare)
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Van Osch, Thijs L.J.Sanquin Research,Academic Medical Center of University of Amsterdam (AMC)
(författare)
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Mok, Juk YeeSanquin Reagents
(författare)
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Brasser, GisoSanquin Reagents
(författare)
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Geerdes, Dionne M.Sanquin Reagents
(författare)
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Koeleman, Carolien A.M.Leiden University Medical Centre
(författare)
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Nouta, JanLeiden University Medical Centre
(författare)
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Semple, John W.Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)jo0201se
(författare)
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Porcelijn, LeendertSanquin Diagnostic Services
(författare)
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Van Esch, Wim J.E.Sanquin Reagents
(författare)
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Wuhrer, ManfredLeiden University Medical Centre
(författare)
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Van Der Schoot, C. EllenSanquin Research,Academic Medical Center of University of Amsterdam (AMC)
(författare)
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Vidarsson, GesturAcademic Medical Center of University of Amsterdam (AMC),Sanquin Research
(författare)
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Kapur, RickAcademic Medical Center of University of Amsterdam (AMC),Sanquin Research(Swepub:lu)ri1121ka
(författare)
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Sanquin ResearchAcademic Medical Center of University of Amsterdam (AMC)
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Blood Advances: American Society of Hematology4:16, s. 3875-38852473-95292473-9537
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Van Der Laan, Ev ...
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