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CMR feature trackin...
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Bratis, KonstantinosOnassis Cardiac Surgery Center, Athens
(författare)
CMR feature tracking in cardiac asymptomatic systemic sclerosis : Clinical implications
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2019-08-21
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Public Library of Science (PLoS),2019
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:3a205417-9da2-4681-814c-6097b97b95ea
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https://lup.lub.lu.se/record/3a205417-9da2-4681-814c-6097b97b95eaURI
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https://doi.org/10.1371/journal.pone.0221021DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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BACKGROUND: Impaired myocardial deformation has been sporadically described in cardiac asymptomatic systemic sclerosis (SSc). We aimed to study myocardial deformation indices in cardiac asymptomatic SSc patients using cardiac magnetic resonance feature tracking (CMR-FT) and correlate these findings to the phenotypic and autoimmune background.METHODS: Fifty-four cardiac asymptomatic SSc patients (44 females, 56±13 years), with normal routine cardiac assessment and CMR evaluation, including cine and late gadolinium enhancement (LGE) images, were included. SSc patients were compared to 21 sex- and age- matched healthy controls (17 females; 54±19 years). For CMR-FT analysis, a mid-ventricular slice for LV peak systolic radial and circumferential strain and a 4-chamber view for LV/RV peak systolic longitudinal strain were used.RESULTS: Twenty-four patients had diffuse cutaneous SSc and 30 limited cutaneous SSc. Thirteen patients had digital ulcers. Median disease duration was 3.6 years. LV ejection fraction was higher in SSc patients compared to controls (62±6% vs. 59±5%, p = 0.01). Four patients had no LGE examination; in the remaining patients LGE was absent in 74%, while 18% had RV insertion fibrosis and 8% evidence of subendocardial infarction. LV longitudinal strain differed in those with insertion fibrosis (-18.0%) and infarction (-16.7%) compared to no fibrosis (-20.3%, p = 0.04). Patients with SSc had lower RV longitudinal strain and strain rate compared to controls (p<0.001 and p = 0.01, respectively). All other strain and strain rate measurements were non-significant between patients and controls.CONCLUSIONS: In cardiac asymptomatic SSc patients with normal routine functional indices, CMR-FT identifies subclinical presence of insertion fibrosis and/or myocardial infarction by impaired LV longitudinal strain. RV derived longitudinal indices were impaired in the patient group. CMR FT indices did not correlate to the patients' phenotypic and autoimmune features.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Lindholm, AnthonyLund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital(Swepub:lu)an2085li
(författare)
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Hesselstrand, RogerLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Forskargruppen för systemisk skleros, Lund,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Systemic Sclerosis Research Group,Lund University Research Groups,Skåne University Hospital(Swepub:lu)reum-rhe
(författare)
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Arheden, HåkanLund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital(Swepub:lu)klfy-har
(författare)
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Karabela, GeorgiaNaval Hospital
(författare)
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Stavropoulos, EfthymiosNaval Hospital
(författare)
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Katsifis, GikasNaval Hospital
(författare)
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Kolovou, GenovefaOnassis Cardiac Surgery Center, Athens
(författare)
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Kitas, George DUniversity of Manchester
(författare)
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Sfikakis, Petros PLaikon General Hospital
(författare)
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Koutsogeorgopoulou, LoukiaLaikon General Hospital
(författare)
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Mavrogeni, Sophie
(författare)
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Ostenfeld, EllenLund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-eos
(författare)
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Onassis Cardiac Surgery Center, AthensKlinisk fysiologi, Lund
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:PLoS ONE: Public Library of Science (PLoS)14:8, s. 1-131932-6203
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Bratis, Konstant ...
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Lindholm, Anthon ...
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Hesselstrand, Ro ...
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Arheden, Håkan
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Karabela, Georgi ...
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Stavropoulos, Ef ...
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Katsifis, Gikas
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Kolovou, Genovef ...
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Kitas, George D
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Sfikakis, Petros ...
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Koutsogeorgopoul ...
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Mavrogeni, Sophi ...
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Ostenfeld, Ellen
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reumatologi och ...
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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Lunds universitet