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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06803naa a2200901 4500 | |
| 001 | oai:lup.lub.lu.se:3ae3ad11-1e91-43ad-8759-f5925e310365 | |
| 003 | SwePub | |
| 008 | 181113s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/3ae3ad11-1e91-43ad-8759-f5925e3103652 URI |
| 024 | 7 | a https://doi.org/10.1016/j.joca.2018.08.0012 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Watt, F. E.u University of Oxford4 aut |
| 245 | 1 0 | a Towards prevention of post-traumatic osteoarthritis : report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury |
| 264 | 1 | b Elsevier BV,c 2019 |
| 520 | a Objective: There are few guidelines for clinical trials of interventions for prevention of post-traumatic osteoarthritis (PTOA), reflecting challenges in this area. An international multi-disciplinary expert group including patients was convened to generate points to consider for the design and conduct of interventional studies following acute knee injury. Design: An evidence review on acute knee injury interventional studies to prevent PTOA was presented to the group, alongside overviews of challenges in this area, including potential targets, biomarkers and imaging. Working groups considered pre-identified key areas: eligibility criteria and outcomes, biomarkers, injury definition and intervention timing including multi-modality interventions. Consensus agreement within the group on points to consider was generated and is reported here after iterative review by all contributors. Results: The evidence review identified 37 studies. Study duration and outcomes varied widely and 70% examined surgical interventions. Considerations were grouped into three areas: justification of inclusion criteria including the classification of injury and participant age (as people over 35 may have pre-existing OA); careful consideration in the selection and timing of outcomes or biomarkers; definition of the intervention(s)/comparator(s) and the appropriate time-window for intervention (considerations may be particular to intervention type). Areas for further research included demonstrating the utility of patient-reported outcomes, biomarkers and imaging outcomes from ancillary/cohort studies in this area, and development of surrogate clinical trial endpoints that shorten the duration of clinical trials and are acceptable to regulatory agencies. Conclusions: These considerations represent the first international consensus on the conduct of interventional studies following acute knee joint trauma. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi0 (SwePub)303012 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Health Care Service and Management, Health Policy and Services and Health Economy0 (SwePub)303012 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
| 653 | a Clinical trial | |
| 653 | a Considerations | |
| 653 | a Injury | |
| 653 | a Knee | |
| 653 | a Osteoarthritis | |
| 653 | a Outcome | |
| 700 | 1 | a Corp, N.u Keele University4 aut |
| 700 | 1 | a Kingsbury, S. R.u University of Leeds4 aut |
| 700 | 1 | a Frobell, R.u Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)sjuk-rfr |
| 700 | 1 | a Englund, M.u Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)ort-med |
| 700 | 1 | a Felson, D. T.u Boston University,University of Manchester4 aut |
| 700 | 1 | a Levesque, M.u AbbVie Inc.4 aut |
| 700 | 1 | a Majumdar, S.u University of Texas Health Science Centre4 aut |
| 700 | 1 | a Wilson, C.u Cardiff University4 aut |
| 700 | 1 | a Beard, D. J.u University of Oxford4 aut |
| 700 | 1 | a Lohmander, L. S.u Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)ort-slo |
| 700 | 1 | a Kraus, V. B.u Duke University4 aut |
| 700 | 1 | a Roemer, F.u Friedrich-Alexander University Erlangen-Nürnberg,Boston University4 aut0 (Swepub:lu)med-fkr |
| 700 | 1 | a Conaghan, P. G.u University of Leeds4 aut |
| 700 | 1 | a Mason, D. J.u Cardiff University4 aut |
| 700 | 1 | a Adams, J.u University of Southampton4 aut |
| 700 | 1 | a Blank, M.4 aut |
| 700 | 1 | a Batt, M.u University of Nottingham4 aut |
| 700 | 1 | a Biggs, P.u Cardiff University4 aut |
| 700 | 1 | a Busse-Morris, M.u Cardiff University4 aut |
| 700 | 1 | a Button, K.u Cardiff University4 aut |
| 700 | 1 | a Calder, J.4 aut |
| 700 | 1 | a Cook, J.u University of Oxford4 aut |
| 700 | 1 | a Edwards, C.u University of Southampton4 aut |
| 700 | 1 | a Fisheleva, E.4 aut |
| 700 | 1 | a Hamilton, D. F.u University of Edinburgh4 aut |
| 700 | 1 | a Harrison, H.4 aut |
| 700 | 1 | a Holt, C.u Cardiff University4 aut |
| 700 | 1 | a Jones, M.4 aut |
| 700 | 1 | a Jones, R.u University of Salford4 aut |
| 700 | 1 | a Kluzek, S.u University of Oxford4 aut |
| 700 | 1 | a Knight, T.4 aut |
| 700 | 1 | a Nuki, G.u University of Edinburgh4 aut |
| 700 | 1 | a Parekh, S.u University College London4 aut |
| 700 | 1 | a Peat, G.u Keele University4 aut |
| 700 | 1 | a Pothet, C.4 aut |
| 700 | 1 | a Rainer, T.u Cardiff University4 aut |
| 700 | 1 | a Robinson, N.u London South Bank University4 aut |
| 700 | 1 | a Sawle, L.u Cardiff University4 aut |
| 700 | 1 | a Vincent, T.4 aut |
| 700 | 1 | a Williams, A.4 aut |
| 700 | 1 | a Wise, E.4 aut |
| 700 | 1 | a Zhang, W.u University of Nottingham4 aut |
| 700 | 1 | a Bierma-Zeinstra, S.u Erasmus University Medical Center4 aut |
| 710 | 2 | a University of Oxfordb Keele University4 org |
| 773 | 0 | t Osteoarthritis and Cartilaged : Elsevier BVg 27:1, s. 23-33q 27:1<23-33x 1063-4584 |
| 856 | 4 | u http://dx.doi.org/10.1016/j.joca.2018.08.001x freey FULLTEXT |
| 856 | 4 | u http://www.oarsijournal.com/article/S1063458418314122/pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/3ae3ad11-1e91-43ad-8759-f5925e310365 |
| 856 | 4 8 | u https://doi.org/10.1016/j.joca.2018.08.001 |
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- Levesque, M.
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