New players in chronic lung disease identified at the European Respiratory Society International Congress in Paris 2018 : From microRNAs to extracellular vesicles

Since the first description of microRNAs (miRNAs) in 1993 (1) a large and growing number of studies has explored their roles across a variety of biomedical research disciplines, including lung biology. According to GENCODE (version 27) (2), 1881 of the >7,500 human small non-coding RNAs are miRNAs. These 20–25 nucleotide-long, regulatory RNAs are involved in the translational regulation of gene expression principally via binding to miRNA recognition elements largely in the 3' untranslated regions of target mRNAs. Upon binding they can induce mRNA degradation, deadenylation or inhibition of their translation, leading to decreased target gene expression (3). Originally described to play important roles in developmental biology, miRNAs have since been found to have significant roles in a multitude of biological processes. Expression levels of miRNAs vary greatly between cells and tissues, and aberrant levels of miRNA are associated with many diseases in humans. In fact, these non-coding RNA molecules are now recognized as major regulators in the development and progression of various chronic lung diseases, including cystic fibrosis (CF), idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD) and asthma (4-9).

Fernandez, Elena FernandezRoyal College of Surgeons in Ireland,Beaumont Hospital, Dublin (författare)
Enes, Sara RolandssonLund University,Lunds universitet,Lungbiologi,Forskargrupper vid Lunds universitet,Lung Biology,Lund University Research Groups,University of Vermont(Swepub:lu)med-sro (författare)
Königshoff, MelanieUniversity of Colorado (författare)
Greene, Catherine M.Beaumont Hospital, Dublin,Royal College of Surgeons in Ireland (författare)
Bartel, SabineResearch Center Borstel (författare)
University of ColoradoRoyal College of Surgeons in Ireland (creator_code:org_t)

Ingår i:Journal of Thoracic Disease: AME Publishing Company10, s. 2983-29872072-14392077-6624

Av författaren/redakt...: Burgy, Olivier; Fernandez, Elena ...; Enes, Sara Rolan ...; Königshoff, Mela ...; Greene, Catherin ...; Bartel, Sabine

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Lungmedicin och ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.