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Protein Quality Con...
Protein Quality Control Pathways at the Crossroad of Synucleinopathies
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- De Mattos, Eduardo P. (författare)
- University of Groningen,University Medical Center Groningen
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- Wentink, Anne (författare)
- Heidelberg University,German Cancer Research Centre
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- Nussbaum-Krammer, Carmen (författare)
- German Cancer Research Centre,Heidelberg University
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- Hansen, Christian (författare)
- Lund University,Lunds universitet,Molekylär neurobiologi,Forskargrupper vid Lunds universitet,Molecular Neurobiology,Lund University Research Groups
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- Bergink, Steven (författare)
- University Medical Center Groningen
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- Melki, Ronald (författare)
- François Jacob Institute of biology
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- Kampinga, Harm H. (författare)
- University Medical Center Groningen
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(creator_code:org_t)
- 2020
- 2020
- Engelska 14 s.
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Ingår i: Journal of Parkinson's Disease. - 1877-7171. ; 10:2, s. 369-382
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- The pathophysiology of Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and many others converge at alpha-synuclein (α-Syn) aggregation. Although it is still not entirely clear what precise biophysical processes act as triggers, cumulative evidence points towards a crucial role for protein quality control (PQC) systems in modulating α-Syn aggregation and toxicity. These encompass distinct cellular strategies that tightly balance protein production, stability, and degradation, ultimately regulating α-Syn levels. Here, we review the main aspects of α-Syn biology, focusing on the cellular PQC components that are at the heart of recognizing and disposing toxic, aggregate-prone α-Syn assemblies: molecular chaperones and the ubiquitin-proteasome system and autophagy-lysosome pathway, respectively. A deeper understanding of these basic protein homeostasis mechanisms might contribute to the development of new therapeutic strategies envisioning the prevention and/or enhanced degradation of α-Syn aggregates.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- Alpha-synuclein
- autophagy
- molecular chaperones
- protein aggregation
- protein homeostasis
- synucleinopathies
- ubiquitin-proteasome system
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