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Clonal haematopoies...
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Schuermans, ArtMassachusetts General Hospital,Broad Institute
(författare)
Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias
- Artikel/kapitelEngelska2024
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LIBRIS-ID:oai:lup.lub.lu.se:3c25f5b7-a438-4384-8bfc-7fa1793baa3d
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https://lup.lub.lu.se/record/3c25f5b7-a438-4384-8bfc-7fa1793baa3dURI
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https://doi.org/10.1093/eurheartj/ehad670DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Background and Clonal haematopoiesis of indeterminate potential (CHIP), the age-related expansion of blood cells with preleukemic mutaAims tions, is associated with atherosclerotic cardiovascular disease and heart failure. This study aimed to test the association of CHIP with new-onset arrhythmias.Methods UK Biobank participants without prevalent arrhythmias were included. Co-primary study outcomes were supraventricular arrhythmias, bradyarrhythmias, and ventricular arrhythmias. Secondary outcomes were cardiac arrest, atrial fibrillation, and any arrhythmia. Associations of any CHIP [variant allele fraction (VAF) ≥ 2%], large CHIP (VAF ≥10%), and gene-specific CHIP subtypes with incident arrhythmias were evaluated using multivariable-adjusted Cox regression. Associations of CHIP with myocardial interstitial fibrosis [T1 measured using cardiac magnetic resonance (CMR)] were also tested. Results This study included 410 702 participants [CHIP: n = 13 892 (3.4%); large CHIP: n = 9191 (2.2%)]. Any and large CHIP were associated with multi-variable-adjusted hazard ratios of 1.11 [95% confidence interval (CI) 1.04–1.18; P = .001] and 1.13 (95% CI 1.05–1.22; P = .001) for supraventricular arrhythmias, 1.09 (95% CI 1.01–1.19; P = .031) and 1.13 (95% CI 1.03–1.25; P = .011) for bradyarrhythmias, and 1.16 (95% CI, 1.00–1.34; P = .049) and 1.22 (95% CI 1.03–1.45; P = .021) for ventricular arrhythmias, respectively. Associations were independent of coronary artery disease and heart failure. Associations were also heterogeneous across arrhythmia subtypes and strongest for cardiac arrest. Gene-specific analyses revealed an increased risk of arrhythmias across driver genes other than DNMT3A. Large CHIP was associated with 1.31-fold odds (95% CI 1.07–1.59; P = .009) of being in the top quintile of myocardial fibrosis by CMR. Conclusions CHIP may represent a novel risk factor for incident arrhythmias, indicating a potential target for modulation towards arrhythmia prevention and treatment.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Vlasschaert, Caitlyn
(författare)
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Nauffal, VictorBrigham and Women's Hospital / Harvard Medical School,Broad Institute
(författare)
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Cho, So Mi JemmaYonsei University,Massachusetts General Hospital,Broad Institute
(författare)
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Uddin, Md MesbahMassachusetts General Hospital,Broad Institute
(författare)
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Nakao, TetsushiDana-Farber Cancer Institute,Broad Institute,Massachusetts General Hospital,Brigham and Women's Hospital / Harvard Medical School
(författare)
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Niroula, AbhishekLund University,Lunds universitet,Hematogenomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Dana-Farber Cancer Institute,Broad Institute(Swepub:lu)med-anu
(författare)
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Klarqvist, Marcus D.R.Broad Institute
(författare)
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Weeks, Lachelle D.Dana-Farber Cancer Institute
(författare)
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Lin, Amy E.Brigham and Women's Hospital / Harvard Medical School,Dana-Farber Cancer Institute
(författare)
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Saadatagah, SeyedmohammadBaylor College of Medicine
(författare)
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Lannery, KimMassachusetts General Hospital,Broad Institute
(författare)
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Wong, MeganMassachusetts General Hospital,Broad Institute
(författare)
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Hornsby, WhitneyMassachusetts General Hospital,Broad Institute
(författare)
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Lubitz, Steven A.Harvard Medical School,Massachusetts General Hospital,Broad Institute
(författare)
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Ballantyne, ChristieBaylor College of Medicine
(författare)
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Jaiswal, SiddharthaStanford University School of Medicine
(författare)
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Libby, PeterBrigham and Women's Hospital / Harvard Medical School
(författare)
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Ebert, Benjamin L.Dana-Farber Cancer Institute,Harvard Medical School,Howard Hughes Medical Institute
(författare)
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Bick, Alexander G.Vanderbilt University Medical Center
(författare)
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Ellinor, Patrick T.Massachusetts General Hospital,Harvard Medical School,Broad Institute
(författare)
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Natarajan, PradeepHarvard Medical School,Massachusetts General Hospital,Broad Institute
(författare)
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Honigberg, Michael C.Massachusetts General Hospital,Harvard Medical School,Broad Institute
(författare)
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Massachusetts General HospitalBroad Institute
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Heart Journal45:10, s. 791-8050195-668X
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Schuermans, Art
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Vlasschaert, Cai ...
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Nauffal, Victor
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Cho, So Mi Jemma
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Uddin, Md Mesbah
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Nakao, Tetsushi
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visa fler...
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Niroula, Abhishe ...
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Klarqvist, Marcu ...
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Weeks, Lachelle ...
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Lin, Amy E.
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Saadatagah, Seye ...
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Lannery, Kim
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Wong, Megan
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Hornsby, Whitney
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Lubitz, Steven A ...
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Ballantyne, Chri ...
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Jaiswal, Siddhar ...
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Libby, Peter
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Ebert, Benjamin ...
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Bick, Alexander ...
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Ellinor, Patrick ...
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Natarajan, Prade ...
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Honigberg, Micha ...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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European Heart J ...
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Lunds universitet