SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:lup.lub.lu.se:3c25f5b7-a438-4384-8bfc-7fa1793baa3d"
 

Sökning: onr:"swepub:oai:lup.lub.lu.se:3c25f5b7-a438-4384-8bfc-7fa1793baa3d" > Clonal haematopoies...

  • Schuermans, ArtMassachusetts General Hospital,Broad Institute (författare)

Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • 2024
  • 15 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:3c25f5b7-a438-4384-8bfc-7fa1793baa3d
  • https://lup.lub.lu.se/record/3c25f5b7-a438-4384-8bfc-7fa1793baa3dURI
  • https://doi.org/10.1093/eurheartj/ehad670DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Background and Clonal haematopoiesis of indeterminate potential (CHIP), the age-related expansion of blood cells with preleukemic mutaAims tions, is associated with atherosclerotic cardiovascular disease and heart failure. This study aimed to test the association of CHIP with new-onset arrhythmias.Methods UK Biobank participants without prevalent arrhythmias were included. Co-primary study outcomes were supraventricular arrhythmias, bradyarrhythmias, and ventricular arrhythmias. Secondary outcomes were cardiac arrest, atrial fibrillation, and any arrhythmia. Associations of any CHIP [variant allele fraction (VAF) ≥ 2%], large CHIP (VAF ≥10%), and gene-specific CHIP subtypes with incident arrhythmias were evaluated using multivariable-adjusted Cox regression. Associations of CHIP with myocardial interstitial fibrosis [T1 measured using cardiac magnetic resonance (CMR)] were also tested. Results This study included 410 702 participants [CHIP: n = 13 892 (3.4%); large CHIP: n = 9191 (2.2%)]. Any and large CHIP were associated with multi-variable-adjusted hazard ratios of 1.11 [95% confidence interval (CI) 1.04–1.18; P = .001] and 1.13 (95% CI 1.05–1.22; P = .001) for supraventricular arrhythmias, 1.09 (95% CI 1.01–1.19; P = .031) and 1.13 (95% CI 1.03–1.25; P = .011) for bradyarrhythmias, and 1.16 (95% CI, 1.00–1.34; P = .049) and 1.22 (95% CI 1.03–1.45; P = .021) for ventricular arrhythmias, respectively. Associations were independent of coronary artery disease and heart failure. Associations were also heterogeneous across arrhythmia subtypes and strongest for cardiac arrest. Gene-specific analyses revealed an increased risk of arrhythmias across driver genes other than DNMT3A. Large CHIP was associated with 1.31-fold odds (95% CI 1.07–1.59; P = .009) of being in the top quintile of myocardial fibrosis by CMR. Conclusions CHIP may represent a novel risk factor for incident arrhythmias, indicating a potential target for modulation towards arrhythmia prevention and treatment.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Vlasschaert, Caitlyn (författare)
  • Nauffal, VictorBrigham and Women's Hospital / Harvard Medical School,Broad Institute (författare)
  • Cho, So Mi JemmaYonsei University,Massachusetts General Hospital,Broad Institute (författare)
  • Uddin, Md MesbahMassachusetts General Hospital,Broad Institute (författare)
  • Nakao, TetsushiDana-Farber Cancer Institute,Broad Institute,Massachusetts General Hospital,Brigham and Women's Hospital / Harvard Medical School (författare)
  • Niroula, AbhishekLund University,Lunds universitet,Hematogenomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Dana-Farber Cancer Institute,Broad Institute(Swepub:lu)med-anu (författare)
  • Klarqvist, Marcus D.R.Broad Institute (författare)
  • Weeks, Lachelle D.Dana-Farber Cancer Institute (författare)
  • Lin, Amy E.Brigham and Women's Hospital / Harvard Medical School,Dana-Farber Cancer Institute (författare)
  • Saadatagah, SeyedmohammadBaylor College of Medicine (författare)
  • Lannery, KimMassachusetts General Hospital,Broad Institute (författare)
  • Wong, MeganMassachusetts General Hospital,Broad Institute (författare)
  • Hornsby, WhitneyMassachusetts General Hospital,Broad Institute (författare)
  • Lubitz, Steven A.Harvard Medical School,Massachusetts General Hospital,Broad Institute (författare)
  • Ballantyne, ChristieBaylor College of Medicine (författare)
  • Jaiswal, SiddharthaStanford University School of Medicine (författare)
  • Libby, PeterBrigham and Women's Hospital / Harvard Medical School (författare)
  • Ebert, Benjamin L.Dana-Farber Cancer Institute,Harvard Medical School,Howard Hughes Medical Institute (författare)
  • Bick, Alexander G.Vanderbilt University Medical Center (författare)
  • Ellinor, Patrick T.Massachusetts General Hospital,Harvard Medical School,Broad Institute (författare)
  • Natarajan, PradeepHarvard Medical School,Massachusetts General Hospital,Broad Institute (författare)
  • Honigberg, Michael C.Massachusetts General Hospital,Harvard Medical School,Broad Institute (författare)
  • Massachusetts General HospitalBroad Institute (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Heart Journal45:10, s. 791-8050195-668X

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy