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Indoor PM2.5 from o...
Indoor PM2.5 from occupied residences in Sweden caused higher inflammation in mice compared to outdoor PM2.5
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- Wierzbicka, Aneta (författare)
- Lund University,Lunds universitet,Metalund,Annan verksamhet, LTH,Lunds Tekniska Högskola,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,Centrum för hälsosamma inomhusmiljöer, CHIE,Annan verksamhet, LTH,Other operations, LTH,Faculty of Engineering, LTH,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH,Centre for Healthy Indoor Environments,Other operations, LTH,Faculty of Engineering, LTH,Lund University, Sweden
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- Omelekhina, Yuliya (författare)
- Lund University,Lunds universitet,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,Lunds Tekniska Högskola,Centrum för hälsosamma inomhusmiljöer, CHIE,Annan verksamhet, LTH,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH,Centre for Healthy Indoor Environments,Other operations, LTH,Faculty of Engineering, LTH,Lund University, Sweden
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- Saber, Anne Thoustrup (författare)
- The National Research Centre for the Working Environment,National Research Centre for the Working Environment, Denmark
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- Bloom, Erica (författare)
- RISE,Bygg och fastighet,Research Institutes of Sweden (RISE)
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- Gren, Louise (författare)
- Lund University,Lunds universitet,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,Lunds Tekniska Högskola,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH,Lund University, Sweden
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- Poulsen, Sarah Søs (författare)
- The National Research Centre for the Working Environment,National Research Centre for the Working Environment, Denmark
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- Strandberg, Bo (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups,Lund University, Sweden; Region Skåne, Sweden
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- Pagels, Joakim (författare)
- Lund University,Lunds universitet,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,Lunds Tekniska Högskola,LTH profilområde: Aerosoler,LTH profilområden,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH,Lund University, Sweden
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- Jacobsen, Nicklas Raun (författare)
- The National Research Centre for the Working Environment,National Research Centre for the Working Environment, Denmark
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(creator_code:org_t)
- 2022-12-12
- 2022
- Engelska 15 s.
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Ingår i: Indoor Air. - : Hindawi Limited. - 0905-6947 .- 1600-0668. ; 32:12
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- We spend most of our time indoors; however, little is known about the effects of exposure to aerosol particles indoors. We aimed to determine differences in relative toxicity and physicochemical properties of PM 2.5 collected simultaneously indoors (PM 2.5 INDOOR ) and outdoors (PM 2.5 OUTDOOR ) in 15 occupied homes in southern Sweden. Collected particles were extracted from filters, pooled (indoor and outdoor separately), and characterized for chemical composition and endotoxins before being tested for toxicity in mice via intratracheal instillation. Various endpoints including lung inflammation, genotoxicity, and acute-phase response in lung and liver were assessed 1, 3, and 28 days post-exposure. Chemical composition of particles used in toxicological assessment was compared to particles analyzed without extraction. Time-resolved particle mass and number concentrations were monitored. PM 2.5 INDOOR showed higher relative concentrations (μg mg -1 ) of metals, PAHs, and endotoxins compared to PM 2.5 OUTDOOR . These differences may be linked to PM 2.5 INDOOR causing significantly higher lung inflammation and lung acute-phase response 1 day post-exposure compared to PM 2.5 OUTDOOR and vehicle controls, respectively. None of the tested materials caused genotoxicity. PM 2.5 INDOOR displayed higher relative toxicity than PM 2.5 OUTDOOR under the studied conditions, that is, wintertime with reduced air exchange rates, high influence of indoor sources, and relatively low outdoor concentrations of PM. Reducing PM 2.5 INDOOR exposure requires reduction of both infiltration from outdoors and indoor-generated particles.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Animals
- Mice
- Air Pollutants/analysis
- Air Pollution, Indoor/adverse effects
- Environmental Monitoring
- Particle Size
- Acute-Phase Reaction
- Sweden
- Particulate Matter/analysis
- Pneumonia/etiology
- aerosol, home, indoor/outdoor ratio, physicochemical characteristics, PM2.5, real-life exposure, toxicity
- aerosol
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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