Sökning: onr:"swepub:oai:lup.lub.lu.se:3d414414-f96d-407d-ac3f-ba33611f898e" > Sequencing of 640,0...
Fältnamn | Indikatorer | Metadata |
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000 | 06810naa a2201021 4500 | |
001 | oai:lup.lub.lu.se:3d414414-f96d-407d-ac3f-ba33611f898e | |
003 | SwePub | |
008 | 210823s2021 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/3d414414-f96d-407d-ac3f-ba33611f898e2 URI |
024 | 7 | a https://doi.org/10.1126/science.abf86832 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Akbari, Parsau Regeneron Pharmaceuticals, Inc.4 aut |
245 | 1 0 | a Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity |
264 | 1 | b American Association for the Advancement of Science (AAAS),c 2021 |
520 | a Large-scale human exome sequencing can identify rare protein-coding variants with a large impact on complex traits such as body adiposity. We sequenced the exomes of 645,626 individuals from the United Kingdom, the United States, and Mexico and estimated associations of rare coding variants with body mass index (BMI). We identified 16 genes with an exome-wide significant association with BMI, including those encoding five brain-expressed G protein-coupled receptors (CALCR, MC4R, GIPR, GPR151, and GPR75). Protein-truncating variants in GPR75 were observed in ∼4/10,000 sequenced individuals and were associated with 1.8 kilograms per square meter lower BMI and 54% lower odds of obesity in the heterozygous state. Knock out of Gpr75 in mice resulted in resistance to weight gain and improved glycemic control in a high-fat diet model. Inhibition of GPR75 may provide a therapeutic strategy for obesity. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Gilani, Ankitu New York Medical College4 aut |
700 | 1 | a Sosina, Olukayodeu Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Kosmicki, Jack A.u Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Khrimian, Loriu Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Fang, Yi Yau Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Persaud, Trikaldarshiu Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Garcia, Victoru New York Medical College4 aut |
700 | 1 | a Sun, Dylanu Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Li, Alexanderu Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Mbatchou, Joelleu Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Locke, Adam E.u Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Benner, Christianu Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Verweij, Nieku Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Lin, Nanu Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Hossain, Sakibu New York Medical College4 aut |
700 | 1 | a Agostinucci, Kevinu New York Medical College4 aut |
700 | 1 | a Pascale, Jonathan V.u New York Medical College4 aut |
700 | 1 | a Dirice, Ercumentu New York Medical College4 aut |
700 | 1 | a Dunn, Michaelu Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Kraus, William E.u Duke University Medical Center4 aut |
700 | 1 | a Shah, Svati H.u Duke University Medical Center4 aut |
700 | 1 | a Chen, Yii Der I.u University of California, Los Angeles4 aut |
700 | 1 | a Rotter, Jerome I.u University of California, Los Angeles4 aut |
700 | 1 | a Rader, Daniel J.u University of Pennsylvania4 aut |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)endo-ome |
700 | 1 | a Still, Christopher D.u Geisinger Health System4 aut |
700 | 1 | a Mirshahi, Tooraju Geisinger Health System4 aut |
700 | 1 | a Carey, David J.u Geisinger Health System4 aut |
700 | 1 | a Berumen-Campos, Jaimeu National Autonomous University of Mexico4 aut |
700 | 1 | a Kuri-Morales, Pablou National Autonomous University of Mexico4 aut |
700 | 1 | a Alegre-Díaz, Jesusu National Autonomous University of Mexico4 aut |
700 | 1 | a Torres, Jason M.u University of Oxford4 aut |
700 | 1 | a Emberson, Jonathan R.u University of Oxford4 aut |
700 | 1 | a Collins, Roryu University of Oxford4 aut |
700 | 1 | a Balasubramanian, Suganthiu Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Hawes, Aliciau Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Jones, Marcusu Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Zambrowicz, Brianu Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Murphy, Andrew J.u Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Paulding, Charlesu Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Coppola, Giovanniu Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Overton, John D.u Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Reid, Jeffrey G.u Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Shuldiner, Alan R.u Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Cantor, Michaelu Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Kang, Hyun M.u Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Abecasis, Goncalo R.u Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Karalis, Katiau Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Economides, Aris N.u Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Marchini, Jonathanu Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Yancopoulos, George Du Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Sleeman, Mark W.u Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Altarejos, Judithu Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Gatta, Giusy Dellau Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Tapia-Conyer, Robertou National Autonomous University of Mexico4 aut |
700 | 1 | a Schwartzman, Michal L.u New York Medical College4 aut |
700 | 1 | a Baras, Arisu Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Ferreira, Manuel A. R.u Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Lotta, Luca A.u Regeneron Pharmaceuticals, Inc.4 aut |
710 | 2 | a Regeneron Pharmaceuticals, Inc.b New York Medical College4 org |
710 | 2 | a Regeneron Genetics Center |
710 | 2 | a DiscovEHR Collaboration |
773 | 0 | t Scienced : American Association for the Advancement of Science (AAAS)g 373:6550q 373:6550x 0036-8075x 1095-9203 |
856 | 4 | u http://dx.doi.org/10.1126/science.abf8683y FULLTEXT |
856 | 4 | u https://www.ukbiobank.ac.uk/media/ezrderzw/applicant-mta.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/3d414414-f96d-407d-ac3f-ba33611f898e |
856 | 4 8 | u https://doi.org/10.1126/science.abf8683 |
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