Sökning: onr:"swepub:oai:lup.lub.lu.se:3d72e9e7-ed48-4e19-b0d1-92619a104ee0" >
Comparison between ...
Comparison between patients included in randomized controlled trials of ischemic heart disease and real-world data. A nationwide study
-
- Laursen, Peter Nørkjær (författare)
- Copenhagen University Hospital
-
- Holmvang, Lene (författare)
- Copenhagen University Hospital
-
- Lønborg, Jacob (författare)
- Copenhagen University Hospital
-
visa fler...
-
- Køber, Lars (författare)
- Copenhagen University Hospital
-
- Høfsten, Dan E. (författare)
- Copenhagen University Hospital
-
- Helqvist, Steffen (författare)
- Copenhagen University Hospital
-
- Clemmensen, Peter (författare)
- Nykøbing Falster Hospital,University Medical Center Hamburg-Eppendorf,University of Southern Denmark
-
- Kelbæk, Henning (författare)
- Zealand University Hospital
-
- Jørgensen, Erik (författare)
- Copenhagen University Hospital
-
- Lassen, Jens Flensted (författare)
- Copenhagen University Hospital
-
- Pedersen, Frants (författare)
- Copenhagen University Hospital
-
- Høi-Hansen, Thomas (författare)
- Gentofte Hospital
-
- Therkelsen, Christian Juhl (författare)
- Aarhus University Hospital
-
- Tilsted, Hans Henrik (författare)
- Aalborg University Hospital
-
- Jensen, Lisette Okkels (författare)
- Odense University Hospital
-
- Nepper-Christensen, Lars (författare)
- Copenhagen University Hospital
-
- Sadjadieh, Golnaz (författare)
- Copenhagen University Hospital
-
- Engstrøm, Thomas (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Copenhagen University Hospital
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska 11 s.
-
Ingår i: American Heart Journal. - : Elsevier BV. - 0002-8703. ; 204, s. 128-138
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: The objective was to compare patients with ischemic heart disease (IHD) undergoing percutaneous coronary intervention (PCI) who were included in randomized controlled trials (RCTs) (trial participants) with patients who were not included (nonparticipants) on a trial-by-trial basis and according to indication for PCI. Methods: In this cohort study, we compared patients with IHD who were randomized in RCTs in relation to undergoing PCI in Denmark between 2011 and 2015 were considered as RCT-participants in this study. The RCT-participants were compared with contemporary nonparticipants with IHD undergoing PCI in the same period, and they were identified using unselected national registry data. The primary end point was all-cause mortality. Results: A total of 10,317 (30%) patients were included in 10 relevant RCTs (trial participants), and a total of 23,644 (70%) contemporary patients did not participate (nonparticipants). In all the included RCTs, nonparticipants had higher hazard ratios for mortality compared to trial participants (P <.001). Among all patients treated with PCI, the pooled estimates showed a significantly higher mortality rate for nonparticipants compared to trial participants (hazard ratio: 2.03, 95% CI: 1.88-2.19) (P <.001). When patients were stratified according to indication for PCI, the pooled estimates showed a significantly lower mortality rate for trial participants compared to nonparticipants in all strata (P for all <.001). Conclusions: Trial participants in recently performed RCTs including patients undergoing PCI were not representative of the general population of patients with IHD treated with PCI according to clinical characteristics and mortality. The difference in mortality was found irrespective of the indication for PCI. Thus, results from RCTs including patients undergoing PCI should be extrapolated with caution to the general patient population.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Laursen, Peter N ...
-
Holmvang, Lene
-
Lønborg, Jacob
-
Køber, Lars
-
Høfsten, Dan E.
-
Helqvist, Steffe ...
-
visa fler...
-
Clemmensen, Pete ...
-
Kelbæk, Henning
-
Jørgensen, Erik
-
Lassen, Jens Fle ...
-
Pedersen, Frants
-
Høi-Hansen, Thom ...
-
Therkelsen, Chri ...
-
Tilsted, Hans He ...
-
Jensen, Lisette ...
-
Nepper-Christens ...
-
Sadjadieh, Golna ...
-
Engstrøm, Thomas
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
American Heart J ...
- Av lärosätet
-
Lunds universitet